Sitagliptin Tablets 50 mg (Sitagliptin Hydrochloride Hydrate)

Adult dose

This medication is administered once daily at a dose of 100 mg for both monotherapy and combination therapy, with a maximum daily dose of 100 mg. It can be taken without regard to meals. Dose adjustment for patients with renal impairment: - For mild renal impairment (eGFR 60-90), no adjustment is necessary. - For moderate renal impairment (eGFR 45-60), no adjustment is necessary. - For moderate renal impairment (eGFR 30-45), the dose is 50 mg once daily.

This medication can rarely cause serious allergic reactions, so if symptoms such as skin rash, difficulty breathing, or swelling of the face or neck occur after taking the medication, it should be stopped immediately and medical attention should be sought. Acute pancreatitis, a serious inflammation of the pancreas, may occur during treatment with this medication; if symptoms such as abdominal pain, vomiting, or nausea develop, consult a physician immediately. It should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and should not be administered to those with a known allergy to this medication or its ingredients. Patients with reduced kidney function should have their dose adjusted, and regular kidney function tests should be performed under the supervision of a physician. During treatment, side effects such as upper respiratory tract infections, nasopharyngitis, headaches, diarrhea, nausea, etc. may occur, and hypoglycemic symptoms may also arise, thus careful blood sugar management is essential. When used in combination with other hypoglycemic agents such as insulin or sulfonylureas, the risk of hypoglycemia increases, and dosage adjustments of the other medications may be considered if necessary. If severe joint pain or skin blisters occur, consult a physician immediately, as the medication may need to be discontinued in such cases. Pregnant or breastfeeding women should avoid using this medication, and safety in children under 18 has not been established. Elderly patients may have decreased kidney function, so regular kidney function tests are recommended during treatment, and dose adjustments may be necessary. In case of overdose, general supportive care should be provided, and blood dialysis may be used to remove some of the medication if needed. The potential for drug interactions with this medication is low, but it is important to consult a physician when taking other medications.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor (severe allergic reaction), severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa (severe skin adverse reactions), wheezing or difficulty breathing, asthma attacks, respiratory distress accompanied by cough and fever (respiratory problems), jaundice (yellowing of the skin or eyes), profound lethargy (liver abnormalities), sudden

Mild side effects

• Upper respiratory tract infections
• nasopharyngitis
• headaches
• diarrhea
• nausea
• dyspepsia
• dizziness
• constipation
• vomiting
• myalgia

This medication should be stored in an airtight container that is well-sealed, and it is recommended to keep it at room temperature between 1°C and 30°C. This helps to maintain the medication's effectiveness and prevents deterioration.

Appearance

Pale yellow pink round film-coated tablets with both sides convex

Package unit

30 tablets/box [10 tablets/PTP×3]