Ducaine Cream

Adult dosage

1. Skin: After applying this medication, cover it with a seal tape. The sealing on the application area should be maintained for 1-3 hours, and at least 1 hour of effectiveness after removing the seal tape should be ensured. 1) For needle insertion (e.g., intravenous cannulation, blood sampling), apply about 2g of this medication for a minimum of 1 hour, maximum of 5 hours. 2) For superficial surgical minor procedures (e.g., excision of epidermoid cyst), apply 1.5-2g/10㎠ for 1 hour.

Children's dosage

Infants aged 3 months to 12 months: total amount 2g, applying to no more than 16㎠.

This medication is used as a local anesthetic and may cause a rare blood disorder known as methemoglobinemia. This condition reduces the blood's capacity to transport oxygen, leading to symptoms such as a bluish discoloration of the skin. Special caution is needed for patients with glucose-6-phosphate dehydrogenase deficiency, congenital or idiopathic methemoglobinemia, those with heart or lung damage, infants under 6 months, and those using oxidizing agents, as they are more sensitive to this symptom. After using this medication, monitoring for symptoms and signs of methemoglobinemia is essential. This medication should not be used in patients with hypersensitivity to the components or amide-type local anesthetics, in areas with wounds or dermatitis, in infants under 3 months, and in infants under 12 months receiving medications that can cause methemoglobinemia, as well as in preterm infants born before 37 weeks of gestation. It should be used cautiously in patients with anemia, methemoglobinemia, or those taking related medications, frail or elderly patients, patients with acute conditions, severe liver disease, and those with allergies to propylene glycol, a component of this medication. Local reactions such as pallor, redness, swelling, itching, and burning may occur, and rare allergic reactions such as hives, angioedema, and bronchospasm may also occur. This medication should not be applied to the eyes or ears as it may cause irritation or toxicity. In case of overdose, symptoms may appear in the central nervous system or cardiac issues, and immediate treatment is necessary, with careful observation for several hours post-treatment. Caution is advised when using this medication during pregnancy or breastfeeding as it may pass through the placenta and be excreted in breast milk. Its safety and efficacy in children, especially infants under 3 months, have not been adequately confirmed, thus usage in mucosal areas is not recommended. Additionally, the risk of methemoglobinemia may increase when used with certain other medications, so be cautious with drug combinations. Lastly, long-term high-dose use of this medication may increase the risk of cancer, so it is essential to strictly adhere to the recommended dosage and duration of use.

Serious side effects

Allergic and anaphylactic reactions such as hives, angioedema, bronchospasm, shock, seizures, coma, arrhythmias, death, symptoms and signs of methemoglobinemia, central nervous system excitation symptoms, central nervous system depression

Mild side effects

• Local pallor
• redness
• swelling
• itching
• initial burning sensation
• corneal irritation
• petechiae
• ecchymosis

This medication should be stored in a tightly closed container to protect it from air and moisture. It is important to maintain the storage temperature between 1 and 30 degrees Celsius to preserve the effectiveness and safety of the medication.

Appearance

white cream

Package unit

500 grams/bottle