Amoksan 375 mg (Amoxicillin-Clavulanate Potassium (2:1))

Adult dose

Adults and children aged 12 years or older or weighing 40 kg or more should take 250 mg/125 mg of Amoxicillin/Clavulanate Potassium orally 3 times a day every 8 hours. In cases of severe and respiratory infections, the dose may be increased to 500 mg/125 mg per administration. For patients with renal impairment, doses should be adjusted based on the creatinine clearance. For creatinine clearance between 10 to 30 mL/min, administer 25 mg of Amoxicillin.

Child dose

Dosing should be adjusted similarly for children under 12 years or weighing less than 40 kg.

This medication is a beta-lactam antibiotic and should not be administered to patients with a history of hypersensitivity to penicillins or cephalosporins. Particularly, caution is needed for patients with infectious mononucleosis or lymphocytic leukemia due to a high risk of rash, and patients who have experienced liver dysfunction or jaundice as a result of this medication or penicillin in the past should avoid it. Patients with reduced liver function or moderate to severe renal disease should be used cautiously as the drug concentration may increase. Patients with a history of allergies, the elderly, those who have difficulty taking orally, or those with gastrointestinal symptoms should also be careful. During treatment, if unusual symptoms such as diarrhea, abdominal pain, rash, shortness of breath occur, the medication should be discontinued immediately and a physician consulted. Severe allergic reactions or anaphylactic shock may rarely occur, so patients should be closely monitored after administration. Regular checks on liver function, kidney function, and blood tests are important during prolonged use. Additionally, this medication may interact with other drugs, so any current medications should be disclosed to healthcare professionals. Pregnant or breastfeeding women should decide on administration after consulting with a physician, and it is advisable to avoid use particularly during the first trimester of pregnancy. In children, it is recommended only for those aged over 12 years or weighing over 40 kg, and the elderly require dosage adjustments and monitoring of their condition. In case of overdose, gastrointestinal symptoms, neurological abnormalities, and allergic reactions may occur, requiring immediate medical attention.

Serious side effects

Urticaria, severe swelling (edema), tightness in the chest, difficulty breathing, cold sweat, paleness, anaphylaxis, skin and mucous membrane syndrome (Stevens-Johnson syndrome), shock, severe allergic reactions, high fever with severe rash, blisters, skin peeling, pain in oral/ocular mucosa, severe skin reactions, dyspnea or difficulty breathing, asthma attacks, respiratory distress accompanying cough and fever, jaundice (yellowing of the skin or eyes)

Mild side effects

Diarrhea, pseudomembranous colitis, dyspepsia, stomatitis, gastritis, glossitis, black hairy tongue, nausea, vomiting, loss of appetite, abdominal pain, bloating, constipation, colonic pain, acid reflux, loose stools, dry mouth, acute pancreatitis, candidiasis, antibiotic-associated colitis, itching, erythema multiforme, angioedema, serum sickness-like syndrome, hypersensitivity vasculitis, acute generalized exanthematous pustulosis, bronchospasm, hematological abnormalities (leukopenia, thrombocytopenia, hemolytic anemia

This medication should be kept in a sealed container to prevent moisture, stored in a dry place at or below 25 degrees Celsius. It is important to store in a cool, dry area since moisture and high temperatures can diminish the drug's effectiveness.

Appearance

White or almost white oval film-coated tablets

Package unit

For domestic use - 100 tablets/PTP [10 tablets x 10]