Niron Plus Injection (Pre-filled) (Sodium Hyaluronate)

Adult administration

Typically, 1 unit is administered once a week for a total of 3 weeks into the joint cavity of the knee or shoulder (shoulder joint cavity, subacromial bursa, or biceps brachii tendon sheaths), but the frequency of administration should be adjusted appropriately according to symptoms. This medication is administered into the joint, so strict aseptic techniques should be followed.

This medication contains sodium hyaluronate as its main ingredient and is used by directly injecting it into the joint to improve its function. First, patients who have previously shown allergic reactions to any of the ingredients should not use this medication. Additionally, patients with a history of allergy to other medications, those with liver function issues, and individuals with skin diseases or infections at the injection site should use it with caution. When using this medication, there is a rare possibility of a serious allergic reaction known as shock; hence, patient status should be closely monitored after administration, and if any abnormal symptoms occur, administration should be stopped immediately, and appropriate treatment should be received. Common side effects may include swelling around the face or eyes, rash, hives, and itching; if these symptoms appear, administration should be ceased and consultation with a physician is necessary. At the injection site, symptoms such as pain, swelling, redness, warmth, and pressure may temporarily occur, so caution is advised. Additionally, symptoms such as nausea, vomiting, and fever may arise. If there is significant inflammation in the joint, this medication may exacerbate the inflammation, so it is advisable to administer it once the inflammation has subsided. After administration, the injection site should be stabilized, ensuring that the medication does not leak out of the joint space. Injections should always be performed under sterile conditions, and if symptoms do not improve, administration should be limited to a maximum of three times and discontinued. If there is a significant accumulation of joint fluid, it is safer to aspirate the fluid before administration. This medication is not intended for intravenous injection or ophthalmic use, and a needle gauge of 22-23 is appropriate. Additionally, caution is necessary as using disinfectants like benzalkonium chloride or chlorhexidine together may cause drug precipitation. Women who are pregnant or may be pregnant should carefully weigh the benefits and risks of using this medication, and it is advisable to avoid breastfeeding during treatment if nursing. Safety for children has not been established, so it should only be used with caution when absolutely necessary. Elderly patients may have reduced bodily functions, so special care is necessary during administration.

Serious side effects

Shock symptoms (severe allergic reaction)

Mild side effects

Hypersensitivity, edema (facial, eyelid, etc.), facial flushing, rash, itching, pain (mostly transient pain after administration), swelling, accumulation of fluid, redness, warmth, severe local pressure, nausea, vomiting, fever

This medication should be stored in a sealed container to prevent air ingress, and it is important to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature. Therefore, avoid extremely hot or cold places, and store it in a cool place away from direct sunlight.

Appearance

A colorless, transparent, and viscous liquid contained in a glass or plastic tube sealed with rubber stoppers (part of a pre-filled syringe system).

Package unit

2 milliliters/pre-filled syringe [2ml x 3 units]