Zenmaril M Tablet 2/500 mg

Adult dose

This drug is administered 1-2 times a day before or with meals. The dosage can be adjusted based on the current treatment regimen, efficacy, and tolerance of each patient, and appropriate blood sugar monitoring is required. Typically, treatment starts with a lower dose, adjusting the dose based on blood sugar levels and medications being taken. In clinical trials, the initial daily dose was 2 mg/500 mg of glymepiride/metformin hydrochloride, based on blood sugar monitoring results.

This drug can cause severe lactic acidosis or hypoglycemia, so it should be discontinued, particularly when there is a rapid decline in renal function. It is important to temporarily stop taking this medication and consult a physician if symptoms such as dehydration, severe diarrhea, vomiting, or fever occur. Patients with reduced kidney function or elderly patients should be especially cautious when using this medication, and regular kidney function tests should be conducted. There is an increased risk of cardiovascular disease, so the cardiovascular condition should be monitored closely during the use of this drug. Patients with insulin-dependent diabetes, acute metabolic acidosis, severe liver or kidney dysfunction, or women who are pregnant or breastfeeding should not use this drug. In addition, the administration of this drug should be temporarily suspended before and after tests involving contrast agents until kidney function stabilizes. Patients at high risk of hypoglycemia, those with poor nutritional status or irregular meals, and patients who consume excessive alcohol should use this drug with extra caution. Gastrointestinal side effects may commonly occur with this drug, and initially may result in nausea, vomiting, or diarrhea, most of which are temporary. If allergic reactions or skin rashes occur, it is important to inform a physician immediately and discontinue use. Hematological abnormalities or vitamin B12 deficiency may occur, so regular blood tests and monitoring of vitamin B12 levels are necessary. This drug may interact with other medications, so if taking other drugs, patients must inform their physician or pharmacist. Particularly when used in conjunction with drugs that increase or decrease blood sugar-lowering effects, blood sugar levels should be monitored closely. Pregnant or breastfeeding women should not use this drug, and if necessary, insulin therapy should be initiated instead. It should be administered cautiously to children and the elderly, and for elderly patients, the dosage should be adjusted considering renal function decline. In case of an overdose, hypoglycemia or lactic acidosis may occur, and immediate contact with a healthcare facility and necessary emergency measures should be taken. During the use of this drug, regular meals, physical activity, and regular monitoring of blood sugar and kidney function should be done to continuously manage the patient's condition. Caution is necessary during driving or machinery operation due to risks of hypoglycemia or other side effects. Keep out of reach of children, and do not transfer to other containers.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, severe allergic reactions, severe skin reactions, liver abnormalities (jaundice), sudden and severe headache, seizures, confusion, paralysis, severe edema or urinary abnormalities, severe thrombocytopenia associated with thrombocytopenic purpura, acute kidney injury, lactic acidosis, loss of consciousness due to hypoglycemia, shock, cardiac arrhythmias, cardiac arrest

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal bloating
• loss of appetite
• indigestion
• constipation
• abdominal pain
• nausea
• palpitations

This medication should be stored in a tightly sealed container to prevent air exposure and is best kept at room temperature between 1 and 30 degrees Celsius. This way of storing helps maintain the drug's effectiveness and prevent degradation.

Appearance

White, rectangular film-coated tablet

Package unit

- - 30 tablets/bottle,- - 100 tablets/bottle