Disena Capsule (Diacerein)

Adult dose

Adults: Administer 50∼100mg of diacerein per day orally in 1∼2 divided doses after meals. Adjust the dose as appropriate according to symptoms. For patients with a history of loose stools or diarrhea, an initial dose of 50mg once daily for the first 2-4 weeks is recommended, followed by 50mg twice daily.

This medication should not be used in patients with inflammatory bowel diseases. This is especially true for patients with conditions such as ulcerative colitis or Crohn's disease. Patients with bowel obstruction syndrome should also avoid this medication. It should be avoided in cases of unexplained abdominal pain. Patients allergic to this medication, its components, or Rhein-type medications should also not use it. It is safe for patients with liver diseases or a history of liver disease to refrain from taking this medication. This medication is not to be used in children under 15 years of age. Since this medication contains lactose, it should not be taken by patients with genetically determined galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption. Patients with a history of small intestine or colon diseases should use this medication cautiously. Women who are pregnant or breastfeeding should use this medication with caution. Elderly patients over 65 years old should use a reduced dosage of this medication. When taking this medication, gastrointestinal symptoms such as diarrhea, loose stools, and abdominal pain may occur. Long-term use may cause serious gastrointestinal issues such as gastrointestinal bleeding, ulcers, and perforations. Rarely, there can be pigmentation of the rectal mucosa. Caution should be taken as severe diarrhea can lead to dehydration and electrolyte imbalance. Skin symptoms such as itching, rashes, and eczema may occur. Liver function abnormalities can occur, so it is advisable to periodically check liver enzyme levels. Long-term use must follow a physician's directive. If diarrhea occurs, stop taking this medication and consult a physician; using it with laxatives should be avoided. Signs of liver damage may arise, so it is essential to observe for hepatotoxic symptoms. Caution is needed when taking other medications that may burden the liver along with this medication, and it is best to limit alcohol consumption. Medications that contain antacids or calcium, magnesium, aluminum can interfere with the absorption of this medication, so a gap of more than 2 hours should be maintained before and after taking this medication. Taking it with diuretics can potentiate diuretic effects, leading to risks of dehydration and hypokalemia, so caution is advised. Co-administration with cardiac glycosides can increase the risk of arrhythmias, hence caution is necessary. During pregnancy, it is advisable to avoid taking this medication as it may affect fetal bone formation. In the case of breastfeeding, it is also preferable to avoid use as components may pass into breast milk in small amounts.

Diarrhea, loose stools, abdominal pain, gastrointestinal disorders (bleeding, ulceration, and perforation), pigmentation of the rectal mucosa, itching, rash, eczema, elevated serum liver enzymes

This medication should be stored in a tightly closed container to protect it from air and moisture. Additionally, it is best to keep the medication at a cool room temperature between 1 and 30 degrees Celsius. This helps to maintain the medication's effectiveness over time.

Appearance

A hard capsule with white upper part and yellow lower part filled with brownish-yellow contents

Package unit

30 capsules/bottle, 500 capsules/bottle