Rosugrine 20 mg (Rosuvastatin Calcium)

Adult dosage

This medication can be taken at any time during the day, irrespective of meals. The initial dose is 5 mg once daily, with a maintenance dose of 10 mg once daily, which most patients will adjust to. The maintenance dose should be appropriately adjusted based on LDL cholesterol levels, treatment goals, and patient response, with increments up to a maximum of 20 mg per day after intervals of 4 weeks or more.

Children's dosage

For pediatric patients with heterozygous familial hypercholesterolemia (ages 10 to 17), the dosage can be administered once daily in the range of 5 mg to 20 mg. The administered dosage should be adjusted based on individual treatment goals.

This medication should not be used in patients with allergies to certain components. It should also not be administered to patients with active liver disease or severe liver function abnormalities. It may pose risks to patients with muscular diseases or myopathy. Patients taking cyclosporine and those with severe renal failure should not use this medication. Pregnant or breastfeeding women, as well as fertile women who are not using appropriate contraception, should avoid using it. Women of childbearing age should only use it after explaining the low likelihood of pregnancy and the potential risks to the fetus. Dosages greater than 40 mg are contraindicated in patients at high risk of myopathy. This medication includes lactose, so it should not be administered to patients with certain genetic disorders such as lactose intolerance. Patients with a history of liver disease or excessive alcohol intake should undergo regular liver function tests. If symptoms of muscle pain or weakness occur, the patient should immediately inform their doctor and undergo evaluation, and in severe cases, the medication should be discontinued. In acute severe conditions, the use of this medication should be halted, and should myasthenia gravis develop, the administration should cease. Caution is advised as concomitant use with specific other medications may increase the risk of muscle-related side effects. Renal function tests may be necessary when taking high doses. Asian patients may exhibit increased drug concentration, necessitating dosage adjustment. This medication can be used in children and adolescents; however, evaluations concerning growth and sexual maturation are limited. Severe skin reactions may occur, so medical attention should be sought immediately if skin changes are observed. Due to numerous medications interacting with this drug, patients must consult their doctor or pharmacist about any concomitant medications. It should not be used during pregnancy or breastfeeding, and women planning a pregnancy should ensure adequate contraception. In case of overdose, there are no specific antidotes; treatment according to symptoms and tests for liver and muscle function are required. This medication does not significantly affect driving or the operation of machinery, but caution is necessary due to the possibility of dizziness.

Serious side effects

Hypersensitivity reactions including hives, angioedema, severe allergic reactions, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), severe skin reactions, dyspnea, difficulty breathing, asthma attacks, respiratory issues, jaundice (yellowing of skin or eyes), hepatitis, liver abnormalities (jaundice), acute renal failure, severe edema with elevated blood pressure (swelling), urinary disturbances, sudden

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• rash
• myalgia
• weakness
• fatigue

This medication should be stored in a tightly closed container to protect it from exposure to air and moisture, and it is safe to store it at room temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain the medication's effectiveness for a longer period.

Appearance

Pink round film-coated tablet

Package unit

30 tablets (15 tablets/PTP x 2)