Trulicity M Tablets 2.5/500mg (Linagliptin, Metformin Hydrochloride)

Adult dose

The dosage of this medication should be determined based on the treatment regimen, efficacy, and tolerability for the patient, not exceeding the maximum daily dose of 2.5 mg of linagliptin and 1000 mg of metformin, taken twice per day. This medication is administered twice daily with meals. 1. If metformin is not being used: The initial dosage is this medication 2.5/500 mg taken twice daily, 1 tablet at a time, and may escalate to 2.5/1000 mg twice daily, 1 tablet at a time.

This medication helps control blood sugar levels. However, there are several precautions to consider when taking this medication. First, patients with poor kidney function should not take this medication, as decreased kidney function can lead to accumulation of the drug in the body which can be hazardous. Furthermore, patients with liver dysfunction or cardiovascular disease should use this medication with caution, as these conditions may exacerbate drug side effects. A rare side effect known as lactic acidosis may occur, which can lead to a dangerously excessive accumulation of lactic acid in the body. Symptoms such as abdominal pain, muscle pain, and difficulty breathing should prompt immediate consultation with a doctor. There is also a risk of hypoglycemia, especially when taken alongside insulin or sulfonylurea medications, so blood sugar levels should be monitored frequently. It is advisable for pregnant women or women who may become pregnant, and nursing mothers to avoid using this medication. Additionally, patients with acute alcohol intoxication or alcohol dependence should avoid taking this medication, as alcohol can increase the risk of drug side effects. For patients undergoing surgery or receiving contrast tests with radioiodine, the use of this medication should be discontinued for a certain period before and after the tests, and it should be resumed only after reevaluating kidney function. This medication is not recommended for children or adolescents as its safety and effectiveness have not been sufficiently established. Elderly patients may experience a decline in kidney function, thus regular monitoring of kidney function and dose adjustment is necessary. When taking this medication, there is a possibility of interaction with other drugs, so it is essential to consult a doctor or pharmacist if taking other medications. Finally, this medication should be kept out of the reach of children and stored away from moisture.

Serious side effects

• Hives
• angioedema
• lactic acidosis
• pancreatitis
• bullous pemphigoid
• liver dysfunction
• hepatitis
• acute myocardial infarction
• heart failure
• pulmonary embolism

Mild side effects

• Nasopharyngitis
• hypersensitivity
• angioedema
• hypoglycemia
• taste disturbance
• cough
• decreased appetite
• diarrhea
• constipation
• nausea

This medication should be stored in a tightly closed container to avoid exposure to air or moisture, and it is best kept at a cool room temperature between 1 to 30 degrees Celsius. This way, the efficacy of the medication can be maintained and degradation can be prevented.

Appearance

Bright yellow, double convex, oval film-coated tablet

Package unit

30 tablets/bottle, 60 tablets/bottle, 100 tablets/bottle, 200 tablets/bottle