AstraiAxon Injection 2 grams (Ceftriaxone Sodium Hydrate)

Adult administration

Adults and children aged 12 years and older: Administer ceftriaxone at 1 to 2 g (potency) intravenously or intramuscularly once daily. For infections caused by pathogens with severe disease or moderate sensitivity, the dose may be increased to 4 g (potency) once daily. The duration and dose for treating microorganisms like meningococcus, Haemophilus influenzae, and Streptococcus pneumoniae vary; for meningitis, the initial dose may be up to 4 g (potency) once daily. In treating gonorrhea:

Child administration

Newborns (up to 14 days old): Administer 20 to 50 mg (potency) per kilogram of body weight once daily, not exceeding 50 mg (potency) per kilogram. Infants and children (15 days to 12 years): Weight-based dosing required.

This medication must not be mixed or administered simultaneously with solutions or drugs containing calcium. In particular, it should never be administered to newborns, as it can form precipitates with calcium and cause severe side effects. It should not be given to patients with hypersensitivity to this drug or with allergies to cephalosporins, penicillin antibiotics, and certain local anesthetics such as lidocaine. Use is also prohibited in premature infants, and newborns with jaundice or hypoalbuminemia, or acidosis. Caution should be exercised when administering this drug to patients with a history of allergic reactions, asthma, or skin rashes, and dose adjustment is required for patients with severely impaired kidney function. Elderly patients and those with poor general health should also be monitored closely, as vitamin K deficiency symptoms may appear, and it is advisable to regularly check coagulation status. Various side effects such as eosinophilia, leukopenia, thrombocytopenia, diarrhea, rash, liver enzyme elevation, headache, dizziness, bronchospasm, nausea, vomiting, itching, hematuria, diabetes, phlebitis, pain at the injection site, fever, edema, chills, elevated serum creatinine, stomatitis, candidiasis, vitamin K deficiency symptoms, vitamin B complex deficiency symptoms, ventricular ectopic beats, sweating, flushing, palpitations, nosebleeds, hypotension, Clostridium difficile-associated diarrhea, and pancreatitis may occur. Therefore, any unusual symptoms should be reported to healthcare providers immediately. Rarely, serious allergic reactions, interstitial pneumonia, renal impairment, and severe skin reactions may occur, so careful observation is essential. To prevent the emergence of resistant bacteria, this drug should only be administered for the minimum required duration determined by sensitivity testing, and liver and kidney function, as well as blood status, should be regularly monitored during treatment. Additionally, this medication may cause dizziness and interact with driving or machine operation, requiring caution. This drug may interact with others, particularly diuretics, aminoglycoside antibiotics, calcium-containing solutions, and vitamin K antagonists, so consultation with healthcare professionals is necessary when using concurrently. Women who are pregnant or breastfeeding should only use this drug if the benefits outweigh the risks, as its safety has not been established. Caution should also be taken when breastfeeding. The safety of this medication in newborns and premature infants has not been established, and it is contraindicated in newborns with high bilirubin levels due to the risk of encephalopathy. Elderly patients with decreased physiological function face a higher risk of adverse effects, necessitating careful observation and adjustment of dosage and administration intervals. This medication may affect results in certain clinical tests, such as urine sugar tests, so caution should be exercised during testing, and during intravenous injection, pain at the site of injection or phlebitis may occur, requiring slow administration and careful monitoring of the injection site. The prepared solution is usually required to be used immediately, and it is safer to use it within a certain period if stored.

Serious side effects

Hives, severe swelling (edema), shock, anaphylaxis, anaphylactoid reactions, severe allergic reactions, severe skin adverse reactions (erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), dyspnea, asthma attacks, liver abnormalities (jaundice), encephalopathy, seizures, confusion, visual disturbances, paralysis, severe renal impairment (acute renal failure), polyuria (severe urinary abnormalities), neurological abnormalities (encephalopathy, seizures, muscular spasms)

Mild side effects

Eosinophilia, leukopenia, thrombocytopenia, diarrhea, rash, increased liver enzymes, headache, dizziness, bronchospasm, nausea, vomiting, itching, hematuria, diabetes, phlebitis, pain at the injection site, fever, edema, chills, elevated serum creatinine, stomatitis, candidiasis, vitamin K deficiency symptoms, vitamin B complex deficiency symptoms, ventricular ectopic beats, sweating, flushing, palpitations, nosebleeds, hypotension, Clostridium difficile-associated diarrhea, pancreatitis

This medication should be stored in a sealed container to prevent air and moisture ingress. The optimal storage temperature is between 1 degree and 30 degrees Celsius at room temperature.

Appearance

A colorless, transparent vial containing white to faintly yellow powder.

Package unit

10 vials/box [(2g/vial)]