Tewintreeaxone 1g (Ceftriaxone Sodium)

Adult dosage

As Ceftriaxone, administer 1-2g (activity units) once daily by intravenous or intramuscular injection. In case of infections caused by severe pathogens or pathogens with moderate susceptibility, the dose may be increased up to 4g (activity units) once daily. For meningitis, the initial dose may be administered up to a maximum of 4g (activity units) once daily. For gonorrhea treatment, a single intramuscular injection of 250mg (activity units) is recommended. For the prevention of post-operative infections, a single dose of 1-2g (activity units) is advisable.

Children's dosage

Neonates (within 14 days of birth): Administer 20-50mg (activity units) per kg of body weight once daily, not to exceed 50mg (activity units). Infants and children (from 15 days to 12 years): Administer 20

This medication should not be mixed or administered concurrently with solutions containing calcium. Particularly in neonates, the interaction between calcium and this drug can cause precipitation, leading to a risk of serious side effects, so it must not be administered. Patients with an allergy to this medication or who have had hypersensitivity reactions to cephalosporins or penicillins should not use it. Furthermore, administering this drug intravenously, if it contains lidocaine, should be avoided. Premature infants or neonates with issues related to bilirubin binding may experience dangerous side effects such as bilirubin encephalopathy if this medication is used, so it should not be administered. While using this medication, various side effects such as allergic reactions, blood disorders, gastrointestinal symptoms, and neurological symptoms may occur, so careful observation is necessary. If symptoms such as rash, hives, difficulty breathing, severe abdominal pain, or diarrhea develop, usage should be stopped immediately and medical assistance should be sought. Regular monitoring of liver and kidney function, as well as blood conditions, is important during treatment to check for abnormalities. This medication may interact with other drugs, so caution should be taken, especially when used alongside diuretics, aminoglycoside antibiotics, and vitamin K antagonists. Women who are pregnant or breastfeeding have not established the safety of this medication, and it should only be used under medical supervision when absolutely necessary, with extra caution required while breastfeeding. Elderly patients or those with impaired kidney function may have increased drug concentrations in their body, so dosing and intervals should be adjusted carefully. This medication may cause side effects such as dizziness when driving or operating machinery, so caution is advised. Prepared solutions should be used as soon as possible, and during storage, specified time and temperature should be observed. Furthermore, this medication and calcium-containing solutions must never be administered through the same injection site, and thorough cleansing of the injection site must be performed.

Serious side effects

Hives, severe swelling (edema), cold sweat, pallor, severe allergic reactions, high fever with severe rash, blisters, skin sloughing, pain in oral/ocular mucosa, severe skin adverse reactions, difficulty breathing or respiratory distress, asthma attacks, respiratory abnormalities with cough and fever, respiratory problems, yellowing of skin or eyes (jaundice), extreme lethargy, liver abnormalities (jaundice), sudden and very severe headaches, thunderclap headaches

Mild side effects

• Eosinophilia
• leukopenia
• thrombocytopenia
• diarrhea
• rash
• increased liver enzymes
• headache
• dizziness
• itching
• hematuria

This medication should be stored in a tightly sealed container to prevent air and moisture from entering, and it is safest to store it at room temperature between 1 degree and 30 degrees Celsius. By doing so, the medication's effectiveness can be maintained and degradation can be prevented.

Appearance

A vial containing a white to pale yellow powder

Package unit

1g X 1 vial, 1g X 10 vials