Endprep

Adult dose

For adults over 18 years, dissolve one pouch of Product A and one pouch of Product B in 500ml of water to prepare the solution. Prepare a total of 500ml of the solution 4 times, and refrigerate if necessary, using within 24 hours. There are two methods of administration: 1) Split dosing method: The preparation solution of 1L (500ml solution prepared 2 times) should be ingested in the evening before the colonoscopy, at 250ml every 15 minutes for 1 hour.

This drug may rarely cause generalized tonic-clonic seizures even in patients without a seizure history, so caution is needed. The risk of seizures increases, especially in patients taking diuretics or ACE inhibitors which may cause electrolyte imbalances. It's essential to check electrolytes, such as sodium, potassium, calcium, creatinine, and BUN, through blood tests before and after a colonoscopy. This drug should not be administered to patients with bowel obstruction, gastrointestinal obstruction, perforation, toxic colitis, or toxic megacolon, and should be used cautiously in patients with severe ulcerative colitis. Additionally, the artificial sweetener aspartame contained in this medicine breaks down into phenylalanine, thus it should not be administered to patients with phenylketonuria. The daily aspartame intake should be controlled to be below the WHO recommended amount, and typically, the maximum dose for an adult weighing 60kg is 2.4g. Patients who are allergic to this drug or its components, suspected of gastrointestinal obstruction or perforation, dehydrated or severely heart failure patients, advanced cancer patients, or those with gastroparesis should not be given this drug. Safety and efficacy have not been established for children under 18 years. Caution is recommended when using this drug in elderly or frail patients, severely impaired kidney function patients, or those with vomiting reflex disorders or dysphagia. This drug can cause various adverse reactions, including hunger, hypophosphatemia, hypokalemia, sleep disorders, dizziness, headache, abdominal pain, nausea, abdominal distension, vomiting, fatigue, thirst, tremors, malaise, decreased bicarbonate in the blood, decreased calcium in the blood, hypercalcemia, decreased or increased chloride in the blood, increased phosphate in the blood, liver dysfunction, runny nose, dermatitis, rash, itching, fever, chills, tremors, kidney dysfunction, and renal failure. Rarely, allergic reactions or gastrointestinal bleeding, esophageal perforation, or acute pulmonary edema may occur, so immediate consultation with medical staff is required if abnormal symptoms arise. Monitor bowel movements during administration, and if abdominal distension or pain worsens, the infusion rate should be reduced or temporarily suspended, and examination and tests should be conducted if necessary. If symptoms of fluid and electrolyte imbalances develop, assess the condition through blood tests and provide appropriate treatment. Patients with heart disease or high risk of electrolyte imbalances should undergo ECG monitoring to carefully observe for arrhythmias. This drug can cause diarrhea, so it’s necessary to ensure adequate hydration before and after administration. The risk of mucosal ulceration or ischemic colitis increases when used with irritant laxatives, so it is advisable to avoid co-administration. It’s safer to finish eating at least 1 hour before administration and not consume solid food. The effect of this drug on driving or operating machinery is unclear, so caution is advised. There may be interactions with other medications, so oral medications should not be taken within 1 hour of administering this drug. Pregnant or nursing women should only use this drug when the benefits outweigh the risks. Overdose may lead to dehydration and severe electrolyte imbalances, so symptoms should be closely monitored and appropriate treatment should be received in case of overdose. Solutions should be taken immediately after preparation, and any unused solution after 24 hours should be discarded, keeping it out of reach of children. When stored in the refrigerator, keep the lid covered and avoid transferring to another container.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, seizures, upper gastrointestinal bleeding, esophageal perforation, anaphylaxis-like reactions, peripheral edema, cardiac arrest, acute pulmonary edema, cardiovascular anomalies (tachycardia, palpitations, hypertension, arrhythmia, atrial fibrillation, syncope), dyspnea, chest tension, tongue swelling, lip swelling, facial swelling, severe skin reactions, severe allergic reactions, serious neurological symptoms.

Mild side effects

Hunger, hypophosphatemia, hypokalemia, sleep disorders, dizziness, headache, upper abdominal pain, abdominal pain, nausea, abdominal distension, anal discomfort, vomiting, indigestion, difficulty swallowing, fatigue, thirst, tremors, malaise, decreased bicarbonate in the blood, decreased calcium in the blood, hypercalcemia, decreased or increased chloride in the blood, increased phosphate in the blood, liver dysfunction, runny nose, dermatitis, rash, itching, fever, chills, tremors, kidney dysfunction, renal failure.

This drug may be sensitive to air or moisture, so it must be stored in a tightly sealed container. It is recommended to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature to preserve the drug's efficacy for a longer period.

Appearance

1) Product A: A white or slightly yellow powder contained in an aluminum foil pouch with a lemon flavor. 2) Product B: White crystals or crystalline powder in an aluminum foil pouch, with no odor and a sour taste.

Package unit

Product A: 56.0818g/pack*4, Product B: 5.3g/pack*4