Samsung Sitagliptin Tablets 100 mg (Sitagliptin Phosphate Monohydrate)

Adult dose

This medication is administered once daily at a dosage of 100 mg for monotherapy or combination therapy, with a maximum daily dosage of 100 mg. This medication can be taken regardless of meals. For patients with renal impairment, dose adjustments are necessary based on renal function. - Mild renal impairment (eGFR 60–90): No dose adjustment needed. - Moderate renal impairment (eGFR 45–60): No dose adjustment needed. - Moderate renal impairment

This medication may rarely cause serious allergic reactions, so if symptoms such as difficulty breathing, swelling of the face or neck, or skin rashes occur within three months after administration, usage should be discontinued immediately and a doctor consulted. During treatment with this medication, symptoms of pancreatitis such as sudden abdominal pain, nausea, and vomiting may occur; if these symptoms arise, inform medical personnel immediately. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, nor in patients who are hypersensitive to this drug or its components. Patients with kidney function impairment should have their dosing adjusted, particularly those with low glomerular filtration rates or those undergoing dialysis should strictly follow a doctor's instructions. While taking this medication, one should watch for hypoglycemic symptoms, and particularly in cases of co-administration with insulin or sulfonylureas, the risk of hypoglycemia may increase, so blood sugar should be monitored frequently. Side effects such as headaches, upper respiratory infections, nasopharyngitis, diarrhea, nausea, and dizziness may occur; if symptoms are severe, it is advisable to consult medical personnel. The use of this medication during pregnancy is not recommended, and it is also safer not to use during breastfeeding. In elderly patients, renal function may decline, therefore dosage adjustment and kidney function monitoring are necessary. In case of an overdose of this medication, immediate hospital visit for appropriate treatment and monitoring is required, and some can be removed through dialysis. During medication, if any abnormal symptoms such as joint pain or skin blisters occur, notify a doctor immediately, and if necessary, medication can be discontinued. Drug interactions are minimal; however, when taken alongside cyclosporine or digoxin, blood concentrations should be monitored. This medication does not significantly impact cardiovascular safety, but patients with existing cardiovascular diseases should have regular check-ups.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, rash, severe skin reactions (Stevens-Johnson syndrome, exfoliative dermatitis), acute pancreatitis, difficulty breathing, severe and disabling joint pain, blistering pemphigoid, acute renal failure, jaundice, severe allergic reactions

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• headache
• constipation
• vomiting
• muscle pain
• limb pain
• back pain
• itching
• thrombocytopenia

This medication should be stored in a sealed container to prevent air or moisture from entering. It is recommended to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature. This helps to retain the efficacy of the medication for a longer period.

Appearance

Beige colored, round, double convex film-coated tablet

Package unit

28 tablets (14 tablets/PTP packaging * 2)