Crevatin 20 mg (Rosuvastatin Calcium)

Adult dosage

The initial dose is 5 mg once daily, and if greater reductions in LDL cholesterol levels are needed, the maintenance dose can be adjusted. The maintenance dose is typically 10 mg once daily, which controls the majority of patients. The maintenance dose should be adjusted appropriately every 4 weeks or longer intervals based on LDL cholesterol levels, treatment goals, and patient response, with a maximum dose of 20 mg daily.

Children's dosage

The usual dosage range for pediatric patients with heterozygous familial hypercholesterolemia (aged 10 to 17 years) is 5 mg to 20 mg once daily. Dosage should be adjusted individually based on the recommended treatment goals for each patient.

This medication should not be used in certain patients. For example, patients who are allergic to this medication, have severe liver dysfunction, have muscle diseases, or have severe kidney disorders should not take it. Women who are pregnant or breastfeeding, as well as women of childbearing age who do not use adequate contraception, must consult a physician before taking this medication, as it may pose risks to the fetus. Additionally, patients with a history of muscle-related disorders or at high risk of muscle damage should avoid high doses of this medication and should closely monitor their muscle condition before and after taking it. This medication contains lactose, making it unsuitable for patients with lactose intolerance or specific genetic metabolic disorders. Patients with liver health issues or those who consume alcohol heavily should have liver function tests before taking this medication and should regularly monitor liver health during treatment. If symptoms such as muscle pain, weakness, or cramps occur, they should promptly inform their physician, and discontinuation of the medication may be required. This medication may interact with various other drugs, so if patients are taking other medications, they must inform their doctor or pharmacist. Caution is especially needed when combined with specific antibiotics, antifungals, immunosuppressants, and fibrates. Pregnant or breastfeeding women, or those planning to become pregnant, should not take this medication and must use adequate contraception. In cases of overdose, there is no specific antidote, so treatment should be based on symptoms, along with liver function and muscle enzyme tests. Caution is required when driving or operating machinery due to potential dizziness or similar symptoms. In rare instances, severe skin reactions, liver damage, or muscle disorders may develop in some patients; if unusual symptoms occur, immediate consultation with healthcare professionals is necessary.

Serious side effects

Allergic reactions including urticaria and angioedema, rash, Stevens-Johnson syndrome, difficulty breathing, liver abnormalities (jaundice), jaundice, liver failure, severe edema, myopathy, rhabdomyolysis, immune-mediated necrotizing myopathy, severe muscle weakness, ocular muscle weakness, polyneuropathy, severe skin reactions, acute renal failure, oliguria, thrombocytopenia

Mild side effects

• Headache
• dizziness
• constipation
• nausea
• abdominal pain
• itching
• muscle pain
• weakness
• hematuria
• diarrhea

This medication must be stored in a tightly closed container to prevent exposure to air and moisture. It is recommended to maintain the storage temperature between 1°C and 30°C.

Appearance

Pink round film-coated tablet

Package unit

30 tablets (15 tablets/PTP (AluAlu) x 2)