Anticran Tablets 375 mg (Amoxicillin and Clavulanate Potassium)

Adult dose

Adults and children aged 12 years and older or weighing over 40 kg should be administered amoxicillin / clavulanate potassium at a dose of 250 mg / 125 mg three times a day orally every 8 hours. In severe and respiratory infections, the dose may be increased to 500 mg / 125 mg. In cases of renal impairment, dosages should be adjusted according to creatinine clearance. - Creatinine clearance over 30 mL/min: dosage adjustment is not necessary.

Child dose

For children aged 12 years and older or weighing over 40 kg, the same dosage applies as for adults. For younger children, the dosage should be adjusted according to renal function using the same method.

This medication is a beta-lactam antibiotic and should not be administered to patients who have had hypersensitivity reactions to penicillin or cephalosporin drugs. Special caution is required for patients with infectious mononucleosis or lymphocytic leukemia due to a higher risk of rash. Patients with liver dysfunction may experience recurrence of liver impairment when using this medication, so caution is advised. Patients with impaired liver function or significant renal impairment should adjust the dosing interval as the drug concentration may be elevated. Patients with allergic tendencies, the elderly, or those in poor nutritional status should be carefully monitored for bleeding risks due to vitamin K deficiency. If gastrointestinal symptoms such as vomiting or diarrhea occur, careful administration is necessary due to potential absorption reductions. This medication may cause gastrointestinal side effects such as diarrhea, nausea, and abdominal pain, and in severe cases, serious conditions such as pseudomembranous colitis may develop. Symptoms of liver dysfunction may occur during treatment or after discontinuation, so regular liver function tests are necessary. Skin rashes, itching, and in severe cases, serious skin reactions such as Stevens-Johnson syndrome may occur, requiring immediate cessation of administration upon symptom occurrence. Blood tests may occasionally reveal abnormalities such as leukopenia and thrombocytopenia, so testing is necessary if such symptoms arise. Central nervous system side effects, though rare, may include headaches, dizziness, and seizures, particularly dangerous in patients with renal impairment. Regular renal function tests are required as there may be sudden deteriorations in renal function, requiring cessation of administration upon discovery of abnormalities. Fungal infections such as stomatitis or candidiasis may occur due to antibiotic use, necessitating appropriate measures upon symptom occurrence. Bleeding tendencies due to vitamin K deficiency may appear, requiring immediate reporting of any bleeding symptoms. To prevent the emergence of resistant bacteria, it is best to use this medication only for the minimum duration after sensitivity testing. Patients with a history of severe allergic reactions to penicillin-class drugs should be particularly cautious and closely monitored for acute allergic reactions such as anaphylaxis. If diarrhea or abdominal pain worsens, the medication should be discontinued immediately, and medical consultation is required. Prolonged use may present a risk of excessive growth of resistant bacteria, thus regular monitoring is necessary if the treatment exceeds 14 days. Pregnant or nursing mothers should exercise caution as the effects on the fetus or infant are not well established and particularly avoid administration in early pregnancy; caution is required during breastfeeding as adverse effects may occur in infants. Pediatric patients are recommended to use this medication only in those 12 years or older or weighing over 40 kg. Elderly patients may experience more pronounced side effects due to reduced physiological capacity, thus the dose and administration interval should be adjusted cautiously. This medication may interact with others, so it is essential to inform healthcare providers of any concurrent medications. In cases of overdose, symptoms such as vomiting, diarrhea, drowsiness, and seizures may occur, necessitating immediate contact with a medical institution for appropriate treatment. Storage should be in a dry place at or below 25 degrees Celsius, and it is crucial not to arbitrarily discontinue or change the dose.

Serious side effects

Urticaria, severe swelling, tightness in the chest, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, mucous membrane pain in the mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities with cough and fever, skin or eyes turning yellow (jaundice), profound lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, significantly reduced urination

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• black hairy tongue
• nausea
• vomiting
• loss of appetite

This medication should be stored in a tightly sealed container to prevent moisture intrusion, ideally kept in a cool place between 1 and 25 degrees Celsius. Avoid direct sunlight, and ensure it is stored away from excessively hot or cold areas to preserve its effectiveness.

Appearance

White or almost white oval film-coated tablets.

Package unit

100 tablets/box [(10 tablets/PTP X 10)]