Duotorin Tablets 10/10mg

Adult dose

This medication is administered once daily in the evening regardless of meals. The dosage range for patients with primary hypercholesterolemia is 10/10mg to 10/40mg daily, and the generally recommended initial dosage is 10/20mg daily. Patients with less need for LDL-cholesterol reduction may start with 10/10mg daily. After initiation or dosage adjustment, lipid levels should be checked at intervals of at least 4 weeks.

This medication is primarily used to lower blood cholesterol levels and help reduce the risk of cardiovascular diseases. When taking this medication, there is a risk of severe muscular side effects such as myopathy or rhabdomyolysis; caution is advised. If muscle pain, weakness, or unexplained muscle aches occur, consult a physician immediately. It is advisable for individuals with liver dysfunction or those with ongoing liver disease to avoid this medication. Additionally, women who are pregnant or breastfeeding should not take this drug. The risk of side effects may increase when taken with certain medications, so if you are taking other drugs, be sure to inform your doctor or pharmacist. Care should be taken to avoid co-administration with potent CYP3A4 inhibitors or certain antibiotics, antiviral agents, and immunosuppressants. Elderly patients, those with hypothyroidism, or those with renal impairment are at an increased risk for myopathy and should be particularly cautious when taking this medication. It is recommended to regularly monitor for muscle-related symptoms and liver function tests when starting this medication or changing dosages, and to report any symptoms to healthcare professionals immediately. Furthermore, as this medication contains lactose, patients with lactose intolerance should not take it. This medication has not been sufficiently proven to be safe and effective in children and adolescents, so caution is required. In the case of overdose, there is no specific antidote, and general treatment will be administered according to the symptoms. Finally, this medication should be used in conjunction with lifestyle improvements, and clinical trials have confirmed its effectiveness in reducing the risk of cardiovascular diseases.

Serious side effects

Hives, angioedema, anaphylaxis, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome), severe skin reactions including erythema multiforme, severe edema, hepatitis, pancreatitis, liver abnormalities (including jaundice), acute renal failure, rhabdomyolysis, myopathy, severe muscle pain, severe muscle weakness, oculomotor weakness, severe headache, altered consciousness, seizures, visual disturbances, paralysis, dyspnea

Mild side effects

• Headache
• diarrhea
• influenza
• upper respiratory tract infection
• myalgia
• limb pain
• fatigue
• nausea
• abdominal pain
• constipation

This medication is sensitive to air and moisture; therefore, it should be stored in a tightly sealed container. Avoid placing it in excessively hot or cold locations, and it is best stored at room temperature between 1°C and 30°C.

Appearance

Biconvex rectangular tablets, white to pale yellow

Package unit

PTP Packaging: 30 tablets