Biswon Tablet

Adult dose

Generally, 2 tablets are administered orally twice a day, regardless of mealtime, in the morning and before bedtime. 1) Gastric and duodenal ulcers: 2 tablets are given 2 times a day or 4 tablets once daily before bedtime. Particularly for duodenal ulcer patients, administering 4 tablets twice a day, morning and before bedtime may yield a higher treatment rate. Ulcer due to NSAID administration or during long-term NSAID use follows the same dosage for preventing gastric and duodenal ulcers. Generally, conditions caused by NSAID administration typically heal within 8 weeks, but healing time may occasionally be extended for some patients. For recurrent ulcer patients, who have shown excellent results with short-term therapy, maintain treatment with 2 tablets once daily before bedtime. 2) Gastroesophageal reflux disease: Administer 2 tablets twice a day for 8 weeks or 4 tablets once daily before bedtime. In severe cases of gastroesophageal reflux disease, the dose may be increased to 4 tablets four times a day. 3) Zollinger-Ellison syndrome: Start treatment with an initial dose of 2 tablets three times a day, and increase the dose as necessary. In severe conditions, as directed by a physician, up to 6 g of ranitidine can be prescribed per day. 4) Peptic ulcer, acute stress ulcer, and upper gastrointestinal bleeding caused by acute mucosal lesions: Once oral administration is feasible, switch from injection to oral intake, administering 2 tablets twice a day. 5) Pre-anesthesia administration (prevention of Mendelson's syndrome): 2 tablets are given 2 hours before anesthesia induction. It is also advisable to administer 2 tablets on the night before surgery.

This medication should not be used in patients undergoing dialysis or those who have had allergic reactions to it. It is also unsafe for patients with a history of acute porphyria, those with impaired kidney function, patients who have undergone upper gastrointestinal surgery, pregnant women or those who may become pregnant, premature infants and newborns, and patients with potassium intake restrictions. Patients with compromised liver function or previous experiences of drug allergies, elderly patients, and patients with a history of kidney disease should use this medication with caution. Patients with gastric ulcers or recently developed dyspeptic symptoms should be checked for malignancy before use, as this medication may mask the symptoms of gastric cancer. Patients with Helicobacter pylori infection along with gastric and duodenal ulcers should undergo eradication therapy; other patients, especially those who are critically ill or have hypophosphatemia, may also require caution. While using this medication, various side effects such as shock, severe allergic reactions, skin rashes, blood abnormalities, liver dysfunction, arrhythmias, digestive symptoms, neurological disturbances, muscle pain may occur, so if any abnormal symptoms are observed, discontinue use immediately and consult a doctor. Avoid long-term use, and if there is no therapeutic effect, consider switching to a different medication. Caution is necessary as there may be an increased risk of pneumonia in elderly patients or those with chronic lung disease, diabetes, and impaired immunity. Patients should avoid driving or operating dangerous machinery if dizziness or drowsiness occurs. This medication may interact with other drugs, so consult with a doctor or pharmacist if taking other medications, especially antacids should be taken with an interval. It is safest for pregnant or nursing women not to use this medication, and it is preferable not to administer it to children. Furthermore, this medication may cause false-positive results in urine protein tests, so caution is necessary during testing. In cases of overdose, emergency treatment such as vomiting or gastric lavage may be needed, and blood dialysis may also be considered. Lastly, this medication may reduce gastric acid secretion, leading to an increase in bacterial growth in the gastrointestinal tract, and long-term use may require ocular examinations.

Serious side effects

• Hives
• severe swelling (angioedema)
• chest tightness (chest pain)
• difficulty breathing (bronchospasm)
• shock (anaphylaxis)
• vascular edema
• severe allergic reactions
• liver abnormalities (including jaundice)
• severe edema
• elevated blood pressure

Mild side effects

• Skin rashes
• fever
• hypotension
• chest pain
• elevated serum enzyme levels
• nausea
• vomiting
• constipation
• diarrhea
• abdominal bloating

This medication should be stored in a tightly sealed container to prevent air from entering, preferably at room temperature between 1 and 30 degrees Celsius. Proper storage helps to maintain the drug’s effectiveness for a longer period.

Appearance

Green round film-coated tablets

Package unit

30 tablets/bottle, 500 tablets/bottle