Simvastatin/Ezetimibe Tablet 10/20

Adult dose

This medication is taken once daily in the evening, irrespective of meals. For patients with primary hypercholesterolemia, the daily dosage ranges from 10/10mg to 10/40mg, with the generally recommended initial dose being 10/20mg per day. Those with a lower need for LDL cholesterol reduction may start at 10/10mg per day. In patients with homozygous familial hypercholesterolemia, the dosage is 10/40mg once daily in the evening.

This medication is predominantly used for treating hypercholesterolemia and helps improve heart and vascular health. When taking this medication, caution is required as serious muscle-related side effects, such as myopathy and rhabdomyolysis, may occur. These side effects may include muscle pain, muscle weakness, and in severe cases, lead to kidney damage. The risk of muscle side effects may increase, especially when taken in high doses or alongside specific medications, so it is essential to inform your doctor or pharmacist if you are taking any other medications. It is safer not to use this medication in patients with compromised liver function or liver disease. Additionally, women who are pregnant or breastfeeding should not take this medication, and women planning to become pregnant should consult with their doctor before use. Taking this medication alongside drugs that inhibit certain enzymes may increase blood concentration and the risk of side effects; therefore, dosage adjustment or discontinuation of this medication may be necessary if you are taking such medications. If unexplained muscle pain or weakness occurs during treatment, notify your doctor immediately, and regular blood tests to check muscle enzyme levels are recommended. This medication should be used more cautiously in elderly patients or those with reduced kidney function, and regular monitoring of liver function and blood glucose levels is advisable. It is recommended to avoid alcohol consumption while taking this medication, and caution is advised with specific foods like grapefruit juice that may affect the medication's effectiveness. For safety and efficacy, this medication should be taken strictly according to the physician's instructions regarding the correct method and dosage, and you should not discontinue or change the dosage on your own.

Serious side effects

Hives, severe swelling (edema), angioedema, chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reactions, high fever with severe rash, blisters, desquamation of skin, pain in oral/ocular mucosa, severe skin abnormal reactions, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities with coughing and fever, jaundice (yellowing of skin or eyes), severe fatigue, liver dysfunction (jaundice), sudden

Mild side effects

Headache, diarrhea, influenza, upper respiratory infection, muscle pain, limb pain, fatigue, abdominal pain, nausea, constipation, dyspepsia, flatulence, vomiting, dizziness, paresthesia, depression, cholelithiasis, cholecystitis, alopecia, pruritus, various skin changes, lichenoid drug rash, gynecomastia, decreased libido, sexual dysfunction (including erectile dysfunction), cataract progression, ocular muscle paralysis, anemia, increased blood creatine phosphokinase (CPK), weight loss

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is best to maintain storage temperatures between 1 and 30 degrees Celsius.

Appearance

White to off-white, double convex, rectangular tablet

Package unit

30 tablets (10 tablets x 3 PTP packages)