Donepin 10 mg (Donepezil Hydrochloride Hydrate)

Adult dose

Administer Donepezil Hydrochloride as 5 mg once daily before bedtime. After 4-6 weeks of administering 5 mg, evaluate the clinical response and increase the dose up to 10 mg if needed. When increasing to 10 mg daily, administer with caution regarding gastrointestinal adverse reactions. For underweight female patients aged 85 and older, the dose should not exceed 5 mg daily, with careful monitoring for adverse reactions.

This medication contains Donepezil Hydrochloride Hydrate as its main ingredient and is primarily used for the treatment of Alzheimer's dementia. This medication should not be administered to certain patients. For example, those who are allergic to this drug or its components, women who are pregnant or may become pregnant, and nursing mothers should not take this medication. Additionally, individuals with genetic lactose intolerance or deficiency of lactase, or those with glucose-galactose malabsorption should not take this medication. Patients with heart disease or cardiac conduction disorders should exercise caution when using this medication, as it may cause cardiac-related side effects such as bradycardia or arrhythmia. Patients taking non-steroidal anti-inflammatory drugs (NSAIDs) or with a history of peptic ulcers should also use this medication cautiously due to the risk of gastrointestinal bleeding or worsening of ulcers. Individuals with a history of asthma or chronic obstructive pulmonary disease should be careful, as this medication may induce bronchoconstriction, worsening symptoms. Patients with extrapyramidal disorders, such as Parkinson's disease, should also be cautious, as symptoms may worsen with this medication. This medication contains a color additive known as Yellow No. 4 (Tartrazine), and those with an allergy to this component should use it with caution. Several side effects may occur with this medication. The most serious side effects include fainting, cardiac arrhythmias, gastrointestinal bleeding, liver dysfunction, seizures, movement disorders, respiratory distress, acute pancreatitis, and acute renal failure. Mild side effects may include nausea, vomiting, diarrhea, dizziness, insomnia, headaches, fatigue, muscle pain, and others. This medication can affect heart function, so patients with heart disease or a history of QT interval prolongation should have their condition monitored regularly through electrocardiograms. Caution is advised when driving or operating machinery during treatment, especially at the beginning of therapy or when adjusting the dose, as dizziness or fatigue may occur. It is advisable not to use this medication during pregnancy, and nursing mothers should avoid it or discontinue breastfeeding. The safety of this medication in children has not been established, so it is not used in pediatric patients. In the case of overdose, severe nausea, vomiting, bradycardia, hypotension, respiratory depression, and seizures may occur, and immediate medical assistance should be sought. This medication may interact with other drugs, so it is essential to consult with a doctor or pharmacist especially when taken with heart medications, antibiotics, antidepressants, antipsychotics, NSAIDs, and others. Store the medication out of reach of children, and it is safer not to transfer it to other containers.

Serious side effects

Fainting, bradycardia, heart block, QT interval prolongation, myocardial infarction, heart failure, peptic ulcers, perforated duodenal perforation, gastrointestinal bleeding, hepatitis, liver dysfunction, jaundice, cerebral seizures, cerebral hemorrhage, cerebrovascular disorders, extrapyramidal disorders (movement disorders, ataxia, motor dysfunction, dyskinesia, tremors, involuntary movements, gait disturbances, abnormal posture, speech disorders), neuroleptic malignant syndrome (stiffness, severe muscle rigidity, etc.)

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• headaches
• fatigue
• drowsiness
• dizziness
• insomnia
• tremors

This medication should be stored in a sealed container to prevent air or moisture from entering. Additionally, it should be stored at room temperature between 1 to 30 degrees Celsius, avoiding extremes of temperature.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle