Bisteran Tablet

Adult dose

Usually administered 2 tablets (given orally) twice a day, regardless of meals, in the morning and before bedtime. 1) Gastric and duodenal ulcers Administer 2 tablets twice a day or 4 tablets once a day before bedtime. Especially for patients with duodenal ulcers, administering 4 tablets twice a day, in the morning and before bedtime, can achieve a higher healing rate. The dosage remains the same in cases of ulcers due to NSAID use or for long-term NSAID prophylaxis against the development of gastric and duodenal ulcers. Generally, conditions arising from NSAID use heal within 4 weeks, though healing times may extend for some patients. For patients with recurrent ulcers, where short-term treatment has shown excellent efficacy, maintenance therapy consists of administering 2 tablets once a day before bedtime. 2) Gastroesophageal reflux disease Administer 2 tablets, twice a day or 4 tablets once a day before bedtime for 8 weeks. However, for severe gastroesophageal reflux disease patients, the dose can be increased to 4 tablets four times a day. 3) Zollinger-Ellison syndrome Begin treatment with an initial dose of 2 tablets three times a day, with potential increases as needed. In severe cases, under the guidance of a physician, doses of up to 6 g per day of ranitidine may be given. 4) Peptic ulcers, acute stress ulcers, and upper gastrointestinal bleeding due to acute mucosal lesions When oral administration becomes possible, switch from injection to oral administration, with a dosing of 2 tablets twice a day. 5) Premedication (Prevention of Mendelson's syndrome) Administer 2 tablets 2 hours before anesthesia induction. Also beneficial to administer 2 tablets the night before surgery.

This drug should not be used in patients with impaired kidney function or those undergoing dialysis. It should also not be administered to patients who have had allergic reactions to this medication or its components. For patients with a history of acute porphyria, this drug may trigger seizures and should be avoided. It should be avoided in patients who have undergone upper gastrointestinal surgery or in pregnant women or women who may become pregnant, as well as in premature infants and newborns. Patients on potassium-restricted diets should also avoid this medication. Patients with liver issues, a history of hypersensitivity, elderly patients, and those with kidney dysfunction should use this medication with caution. Special care is needed when taken with non-steroidal anti-inflammatory drugs, and elderly patients with a history of peptic ulcers should have their conditions monitored regularly. As this medication may mask symptoms of stomach cancer, patients with gastric ulcers or dyspepsia over middle age should verify malignancy before use. Patients with positive Helicobacter pylori infection and gastric or duodenal ulcers should also consider bacterial eradication therapy. Caution is required for severely ill patients in intensive care, those with hypophosphatemia, and patients with dysphagia. While using this medication, rare allergic reactions, blood abnormalities, liver dysfunction, cardiac arrhythmias, gastrointestinal abnormalities, and neuropsychiatric symptoms may occur, and if symptoms appear, immediate consultation with healthcare providers is necessary. Particularly, if dizziness or drowsiness occurs, driving or operating hazardous machinery should be avoided. Long-term use of this medication is not recommended, and if therapeutic effects are absent, switching to another medication is advisable. Regular blood tests and liver and kidney function tests should be performed to check for abnormalities. Elderly patients, those with chronic illnesses, and immunocompromised patients may have a higher risk of pneumonia, so caution is essential. Drug interactions may occur, so if you are taking any other medications, be sure to inform your healthcare provider. Caution is especially required when used with anticoagulants, antibiotics, anticonvulsants, etc., and it is advisable to space out the intervals between taking medications. Pregnant or nursing women should not use this medication, and safety has not been established for children, so administration is not recommended. In the case of overdose, emergency treatment such as vomiting or gastric lavage may be needed, and in severe cases, blood dialysis may be required. This medication may reduce gastric acid secretion, promoting bacterial growth in the gastrointestinal tract, hence it is advisable to have an eye examination during prolonged use.

Serious side effects

• Hives
• angioedema
• bronchospasm
• shock
• anaphylactic shock
• vascular edema
• thrombocytopenia
• agranulocytosis
• pancytopenia
• aplastic anemia

Mild side effects

• Skin rash
• fever
• hypotension
• chest pain
• elevated serum enzyme levels
• nausea
• vomiting
• constipation
• diarrhea
• abdominal bloating

This medication should be stored in a tightly closed container to protect it from air and moisture. Additionally, it is best to keep it at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication.

Appearance

White round film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle