Wisubi Tablets

Adult dose

Generally, 2 tablets orally twice a day, morning and before bedtime, regardless of food intake. 1) Gastric and duodenal ulcers Administer 2 tablets twice a day or 4 tablets once at bedtime. Especially for patients with duodenal ulcers, taking 4 tablets twice a day, morning and before bedtime, can achieve higher treatment rates. It is also utilized in combination therapy to prevent gastric and duodenal ulcers due to the administration of non-steroidal anti-inflammatory drugs or long-term use of non-steroidal anti-inflammatory drugs; the dosage remains the same. Typically, conditions caused by non-steroidal anti-inflammatory drugs heal within 8 weeks, although healing times may occasionally be extended depending on the patient. For patients with recurrent ulcers who showed excellent results with short-term therapy, 2 tablets are administered once at bedtime for maintenance therapy. 2) Gastroesophageal reflux disease Administer 2 tablets twice a day for 8 weeks or 4 tablets once at bedtime. However, in severe cases, the dose can be increased to 4 tablets four times a day. 3) Zollinger-Ellison syndrome Start treatment with an initial dose of 2 tablets three times a day and titrate as needed. In severe cases, under the supervision of a physician, up to 6 g of ranitidine may be given daily. 4) Peptic ulcers, acute stress ulcers, and upper gastrointestinal bleeding due to acute mucosal lesions Once oral administration is possible, switch from injection to 2 tablets orally twice a day. 5) Pre-anesthesia medication (to prevent Mendelson syndrome) Administer 2 tablets 2 hours prior to anesthesia induction. It is preferable to also administer 2 tablets the night before surgery.

This medication should not be used by patients undergoing dialysis or those who have experienced allergic reactions to this medication or its components. This medication is not recommended for patients with a history of acute porphyria, and caution is advised for patients with poor kidney function or those who have undergone upper gastrointestinal surgery. Women who are pregnant or may become pregnant, premature infants, and newborns, as well as patients on a potassium-restricted diet, should avoid using this medication. Patients with liver dysfunction or a history of drug allergies, elderly patients, and those with a history of kidney disorders should use this medication cautiously. Patients taking non-steroidal anti-inflammatory drugs should be particularly careful, and since this medication can mask symptoms of gastric cancer, it is important to confirm malignancy in patients with gastric ulcers or newly occurring dyspeptic symptoms over middle age before treatment. Patients with gastric or duodenal ulcers infected with Helicobacter pylori should undergo eradication therapy. Severely ill patients being treated in intensive care units, patients with hypophosphatemia, and those with swallowing difficulties should also exercise caution when using this medication. This medication can rarely cause shock or severe allergic reactions; therefore, if symptoms arise, administration should be immediately discontinued, and appropriate treatment should be received. Various side effects such as decreased blood cell counts, liver dysfunction, arrhythmias, gastrointestinal symptoms, neuropsychiatric symptoms, myalgia, skin rashes have been reported, so if unusual symptoms occur, immediate consultation with a doctor is necessary. Long-term use is not recommended, and if there is no therapeutic effect, switching to another medication is advised. Elderly patients or those with chronic lung disease, diabetes, or weakened immune systems may have an increased risk of pneumonia when taking this medication, so caution is needed. If dizziness or drowsiness occurs, avoid driving or operating dangerous machinery. This medication may interact with other drugs, so if you are taking other medications, be sure to inform your healthcare provider. It is safer for women who are pregnant or breastfeeding to avoid using this medication, and safety in children has not been established, so administration is not recommended. In case of overdose, emergency treatment such as vomiting or gastric lavage may be necessary, and blood dialysis can be performed if needed. This medication reduces gastric acid secretion, which can promote bacterial growth in the gastrointestinal tract, so regular eye examinations may be needed with long-term use.

Serious side effects

• Hives, angioedema (severe swelling), chest pain (tightness in the chest), anaphylactic shock, bronchospasm (difficulty breathing), hypotension, severe allergic reactions
• Systemic malaise, weakness, subcutaneous or mucosal bleeding, fever (hematological abnormalities)
• Jaundice, hepatitis, liver dysfunction (yellowing of the skin or eyes, general malaise)
• Seizures, altered consciousness, mental confusion, tics due to tonic-clonic seizures, and involuntary movement disorders due to disturbance of regulation.

Mild side effects

• Skin rash
• hives
• angioedema
• fever
• hypotension
• chest pain
• nausea
• vomiting
• constipation
• diarrhea

This medication should be stored in a tightly sealed container to prevent air exposure, ideally at room temperature between 1 to 30 degrees Celsius. Proper storage helps maintain the medication's effectiveness for a longer period.

Appearance

Round white film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle