Amotenion 5 mg (Amlodipine Besylate)

Adult dose

Administer orally 5 mg once daily as amlodipine, and may increase to a maximum of 10 mg daily based on patient response. Adjust according to age and symptoms.

This medication is important to avoid in certain patients. For example, patients who have had an allergy to this medication or to drugs in the same class, nursing women, patients with severe liver dysfunction, patients with severe aortic stenosis, and patients in a state of shock should not take this medication. Moreover, there are patients who require caution when using this medication, such as patients with severe hypotension, patients with kidney failure who require dialysis, the elderly, and pregnant or potentially pregnant women should use this medication cautiously. Possible side effects while taking this medication include flushing, fatigue, swelling, palpitations, dizziness, headache, drowsiness, abdominal pain, and nausea. Rarely, symptoms such as hypotension, skin rash, allergic reactions, muscle pain, joint pain, dyspepsia, cough, and shortness of breath can occur, so if any abnormalities occur, consultation with a healthcare professional should be sought. Patients with heart failure or reduced liver function may experience different effects from this medication, so caution is warranted. Additionally, because this medication remains in the body for a long time, blood pressure may gradually decrease even after discontinuing it, so when taking other antihypertensive agents, adjustments in dosage and intervals are necessary. While this medication is not known to significantly impair the ability to drive or operate machinery, dizziness may occur in some individuals, so caution is warranted. There may be interactions with other medications, especially when taken with certain antibiotics, antihypertensive agents, anticoagulants, or grapefruit juice, so healthcare professionals should be informed and careful monitoring is required. There is a risk of hypotension when combined with some medications, thus caution is necessary. Women who are pregnant or breastfeeding should avoid this medication as its safety is not assured, and unless in special cases, it is not recommended during pregnancy, and breastfeeding should be suspended. It may also be used for children, but safety and efficacy have not been established in children under 6 years of age. In case of overdose, severe hypotension and increased heart rate may occur, necessitating an immediate visit to a medical facility, and gastric lavage or detoxification treatment may be needed if necessary. This medication is known to pose no risk of carcinogenicity or genetic abnormalities even with long-term use.

Serious side effects

• Hives, severe swelling (angioedema), toxic epidermal necrolysis
• Chest tightness, difficulty breathing, respiratory distress, angioedema
• Severe rash with fever, rash, blisters, skin peeling, oral/ocular mucosal pain
• Dermatological adverse reactions (erythema multiforme)
• Yellowing of the skin or eyes (jaundice), hepatitis, elevated liver enzymes
• Cardiac and neurological abnormalities: Myocardial infarction, arrhythmias (including bradycardia, ventricular tachycardia, atrial fibrillation), seizures, altered consciousness

Mild side effects

• Cardiovascular: Flushing, vasculitis, hypotension, palpitations, blood pressure lowering, sinoatrial block or atrioventricular block
• General: Fatigue, swelling, weakness, lethargy, pain, weight increase/decrease, dizziness, headache, drowsiness, insomnia, mood changes, weakness, impaired glucose tolerance
• Gastrointestinal: Abdominal pain, nausea, dry mouth, dyspepsia (gastritis), gingival hypertrophy, pancreatitis, vomiting, changes in bowel habits, diarrhea, loose stools, constipation, precordial pain
• Nervous system: Tension, sensory impairment

This medication should be stored in a tightly sealed container to prevent air exposure and is best kept at room temperature between 1 and 30 degrees. By storing it this way, the efficacy of the medication can be maintained for a longer period.

Appearance

White octagonal tablet

Package unit

30 tablets/bottle, 300 tablets/bottle