Phenimetin Tablet 375 mg [Amoxicillin Hydrate·Clavulanic Acid Potassium (2:1)]

Adult dose

Adults and pediatric patients aged 12 years or older or weighing 40 kg or more are administered 250 mg/125 mg of Amoxicillin/Clavulanic Acid Potassium per dose, three times a day every 8 hours. In cases of severe and respiratory infections, the dose may be increased to 500 mg/125 mg per dose. In the case of renal impairment, the dosage should be adjusted based on creatinine clearance, where patients with creatinine clearance of 10 to 30 mL/min receive the appropriate adjustment.

Child dose

Pediatric patients aged 12 years or older or weighing 40 kg or more are administered the same dosage as adults. Pediatric patients with renal impairment are also adjusted similarly.

This drug should not be used in patients with specific allergic reactions or hypersensitivity to beta-lactam antibiotics. Patients with impaired liver function or moderate to severe renal impairment should use this drug with caution and may require adjustments in dosing intervals. In particular, patients with infectious mononucleosis or lymphocytic leukemia may have an increased risk of rash, so use is generally not recommended. If unusual symptoms such as diarrhea, abdominal pain, rash, or respiratory distress occur while taking this drug, it should be discontinued immediately, and medical consultation should be sought. Regular monitoring of liver function, kidney function, and blood condition is important during prolonged use to check for abnormalities. This drug may interact with other medications, so it is essential to inform healthcare providers of any current medications. Women who are pregnant or breastfeeding should consult their doctor before using this drug, especially during the first three months of pregnancy, when it is advisable to avoid administration. Elderly patients may experience adverse reactions more easily due to diminished bodily functions, necessitating dose adjustments and monitoring of their condition. This drug is not recommended for children, particularly those under 12 years of age or weighing less than 40 kg. In cases of overdose, gastrointestinal symptoms, kidney damage, allergic reactions, etc., may occur, so it is essential to adhere to the prescribed dosage and seek immediate medical attention if any unusual symptoms arise. When storing, keep in a tightly closed container in a dry place below 25 degrees Celsius, avoiding direct sunlight and moist areas.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, anaphylaxis, Stevens-Johnson syndrome, shock, severe allergic reactions, high fever with severe rash, blisters, skin peeling, mucosal pain in mouth/eyes, severe skin adverse reactions, asthma attacks, respiratory distress accompanied by cough and fever, jaundice, extreme lethargy, liver abnormalities (jaundice), sudden and very severe reactions.

Mild side effects

Diarrhea, dyspepsia, stomatitis, gastritis, glossitis, nausea, vomiting, loss of appetite, abdominal pain, abdominal bloating, constipation, colonic pain, hyperacidity, loose stools, dry mouth, acute pancreatitis, candidiasis, colitis, blood in stool, gastrointestinal adverse reactions, elevated AST, ALT, ALP, LDH, hepatitis, cholestatic jaundice, itching, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, vesicular exfoliative dermatitis, acute generalized exanthematous pustulosis.

This drug should be kept in a tightly sealed container to prevent moisture, and should be stored at a cool temperature between 1 and 25 degrees Celsius. This helps maintain the drug's effectiveness over time.

Appearance

White or almost white oval film-coated tablet

Package unit

80 tablets/box [(8 tablets/PTP X 10)], 100 tablets/box [(10 tablets/PTP X 10)]