Armin Tablet

Adult dose

This medication is administered 1–2 times a day either before meals or with meals. Usually, a low dose is initiated and can be gradually increased based on blood sugar monitoring results. In clinical trials, an initial daily dose of 2 mg/500 mg of glimepiride/metformin hydrochloride was given, with experience allowing increases up to 8 mg/2000 mg. Single agent glimepiride generally has no additional effect when administered above 4 mg per day.

This medication may pose a risk of severe lactic acidosis or hypoglycemia, so treatment should be temporarily discontinued and a physician consulted if there is a rapid decline in kidney function or signs of dehydration. This medication should not be used in patients with a kidney function below 45 mL/min/1.73 m² and caution is required in situations where kidney function may change. Since the risk of cardiovascular disease may increase, it is important to thoroughly understand the risks and benefits of this medication in conjunction with other treatments. Do not administer to patients with insulin-dependent diabetes, acute metabolic acidosis, severe liver dysfunction, pregnant or nursing women, or patients with moderate to severe renal impairment. Elderly patients, malnourished individuals, alcohol consumers, and those with liver dysfunction may require special attention due to a high risk of hypoglycemia when taking this medication. This medication may cause gastrointestinal symptoms (diarrhea, nausea, vomiting, etc.), which are usually temporary, but if severe, professional consultation is advised. Allergic reactions or hematological abnormalities may occur, so any unusual symptoms should be reported to medical personnel immediately. Regular monitoring of blood sugar, kidney function, vitamin B12 levels, etc. is necessary while taking this medication. In cases of overdose, hypoglycemia or lactic acidosis may occur, requiring immediate medical treatment. This medication has numerous interactions with other drugs, and those taking other medications must inform their medical personnel. Women who are pregnant or nursing should not use this medication and should switch to insulin therapy if needed. Caution should be exercised when administering to children or the elderly, with particular frequency in monitoring kidney function for the elderly. If blood sugar control is unstable or during stressful situations, medication may be temporarily halted and switched to insulin therapy. Be cautious when driving or operating machinery due to the risk of hypoglycemia.

Serious side effects

• Hives, severe swelling (edema), difficulty breathing, shortness of breath, and possibility of allergic reactions and shock.
• Liver abnormalities: Jaundice of the skin and eyes, potential liver failure.
• Severe hypoglycemia: Possible neurological symptoms, including headache, numbness, confusion, coma, and convulsions.
• Lactic acidosis: Decreased blood pH, increased lactate levels, severe fatigue, weakness, difficulty breathing, altered consciousness, acute renal failure, and death.

Mild side effects

• Gastrointestinal symptoms: Diarrhea, nausea, vomiting, abdominal bloating, loss of appetite, indigestion, constipation, abdominal pain, which commonly occur during the initial treatment and are generally temporary.
• Hematological abnormalities: Thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, granulocytopenia, agranulocytosis, pancytopenia, decreased vitamin B12 and deficiency, and megaloblastic anemia.
• Specific sensory abnormalities: Metallic taste, vision impairment, taste disorders, etc.

This medication may be sensitive to air or moisture; therefore, it should be stored in a tightly sealed container. It is best to keep the storage temperature between 1 to 30 degrees Celsius. Proper storage retains the medication's effectiveness for a longer period.

Appearance

White oval film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle