Simvastatin/Ezetimibe Tablets 10/10

Adult dose

This drug is administered once daily in the evening, regardless of meals. The dosage range for patients with primary hypercholesterolemia is 10/10 mg to 10/40 mg daily, with the generally recommended initial dose being 10/20 mg daily. Patients with lesser need for LDL cholesterol reduction may start with 10/10 mg daily. Adjustments in dosage should occur after a gap of 4 weeks following initiation or dose adjustment, with lipid levels being checked.

This drug is primarily used to lower blood cholesterol levels. Caution is necessary while taking this drug as it may cause muscle issues. If you experience muscle pain or weakness, inform your doctor immediately, as it can progress to severe cases of rhabdomyolysis. This drug can affect liver function, so patients with liver diseases or abnormally high liver enzymes should not take it. Pregnant or breastfeeding women should not take this drug, and women of childbearing age must confirm pregnancy before use. When taking this drug alongside other specific medications, the risk of muscle adverse reactions may increase; thus, consult your doctor or pharmacist before starting any new medications. Elderly patients, those with kidney diseases, or hypothyroidism require special caution while using this drug; regular blood tests are recommended to monitor liver function and muscle condition. Additionally, this drug may raise blood sugar levels in some patients, so those at risk for diabetes should periodically check their blood sugar levels. In cases of overdose, there is no specific antidote; therefore, immediate medical attention is required for appropriate treatment. It is vital to avoid consuming grapefruit juice or certain antibiotics, antifungal agents, and immunosuppressants while taking this drug, and inform medical personnel if you are using these medications. Lastly, this drug is used with limitations in children and adolescents, especially not recommended for those under 10 years old.

Serious side effects

Myopathy, rhabdomyolysis, elevated serum creatine kinase (CK) levels (> 10 times the upper limit of normal), persistent elevation of serum aminotransferase levels (> 3 times the upper limit of normal), hepatitis, pancreatitis, cholestasis jaundice, fulminant hepatic necrosis, cirrhosis, liver failure, urticaria, angioedema, chest tightness, dyspnea, respiratory distress, toxic epidermal necrolysis (Lyell's syndrome), mucocutaneous syndrome (Stevens-Johnson syndrome), polymorphous erythema

Mild side effects

• Headache
• diarrhea
• influenza
• upper respiratory infection
• muscle pain
• limb pain
• fatigue
• nausea
• abdominal pain
• constipation

This drug should be stored in a tightly closed container to protect it from air and moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius to safely preserve the drug's efficacy.

Appearance

Biconvex rectangular tablets, white to pale yellow in color

Package unit

30 tablets (10 tablets/Alu-Alu × 3)