Simvastatin CR Tablets (Simvastatin)

Adult dose

The initial dose is 20 mg of Simvastatin extended-release tablets taken once daily, with a maximum of 40 mg. It can be taken at any time of the day. This medication should not be crushed, divided, or chewed; the whole tablet must be swallowed. Cholesterol levels should be measured regularly after 4 weeks of starting treatment and thereafter to adjust the dosing. If cholesterol levels fall below the target level, the dose should be reduced.

This drug can cause serious muscle-related side effects such as myopathy and rhabdomyolysis, with the risk being higher when taken at high doses, thus caution is needed. This medication should not be taken by individuals who have an allergic reaction to it, have severe liver dysfunction, or are pregnant or breastfeeding. Additionally, the risk of muscle damage may increase when taken with certain medications; therefore, patients should inform their doctor or pharmacist of other medications they are taking. People with impaired liver function or excessive alcohol consumption, reduced kidney function, hypothyroidism, a history of muscle disorders, the elderly, and women should use this medication cautiously. Symptoms such as muscle pain, weakness, or tenderness should be reported to healthcare professionals immediately during treatment, and the medication should be stopped if necessary. Liver dysfunction symptoms have also been reported, so regular liver function tests before and during treatment are important. It should be avoided during pregnancy, as it may harm the fetus, and women planning to become pregnant should use appropriate contraception. Breastfeeding should be avoided while taking this medication, as side effects may occur in nursing infants. This medication is not recommended for children under 10 years old or females before menarche. For the elderly, dose adjustments may be necessary because their response to the medication could differ. Caution must be taken to avoid coadministration with certain foods or drugs such as grapefruit juice, and any side effects should be reported to a physician immediately. In the event of overdose, immediate medical attention should be sought.

Serious side effects

Hives, severe swelling (edema), angioedema, chest tightness, difficulty breathing, respiratory distress, respiratory difficulties with fever, severe edema accompanied by hypertension, skin peeling, pain in oral/ocular mucosa, toxic epidermal necrolysis (Lyell syndrome), Stevens-Johnson syndrome (skin-mucosal syndrome), severe allergic reaction, severe skin reaction, liver abnormalities (jaundice), yellowing of skin or eyes (jaundice), hepatitis

Mild side effects

Abdominal pain, weakness, constipation, diarrhea, dyspepsia, bloating, nausea, headache, upper respiratory tract infection, edema, atrial fibrillation, gastritis, diabetes, myalgia, insomnia, dizziness, bronchiolitis, gout, eczema, urinary tract infection, muscle cramps, arthralgia, some cranial nerve disorders (taste disorders, extraocular muscle dysfunction, facial paralysis, etc.), tremors, sensory abnormalities, peripheral neuropathy, mental instability, anxiety, depression, alopecia, itching, hives, gynecomastia, sexual

This medication must be stored in a tightly sealed container to protect it from air and moisture. It is best to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

White to whitish round film-coated tablets

Package unit

30 tablets/bottle, 300 tablets/bottle