Keral (Dexketoprofen Trometamol)

Adult administration

Postoperative pain: Administer 50mg of dexketoprofen as an intramuscular injection every 8 to 12 hours or as an intravenous infusion every 6 to 8 hours, with the maximum daily allowable dose of 150mg. For intravenous infusion, dilute 50mg in 100mL of 0.9% saline and slowly administer over 30 minutes. Acute low back pain: Administer 50mg of dexketoprofen as an intramuscular injection twice daily.

This medication may increase the risk of gastrointestinal bleeding in individuals who regularly consume more than three drinks of alcohol per day, so consultation with a physician or pharmacist is essential. This drug may affect the cardiovascular system and should be used cautiously in patients with cardiovascular diseases or risk factors, as abnormalities in blood pressure or heart function may occur, requiring careful monitoring for symptom onset. Gastrointestinal adverse effects such as bleeding, ulcers, and perforation may occur; therefore, elderly individuals or those with gastrointestinal diseases should be particularly cautious, and if abdominal pain or bleeding symptoms arise, immediate consultation with medical personnel is necessary. In the case of injectable ampoules, glass fragments may enter when cutting the container, so extreme caution is required while cutting, especially when administering to children or the elderly. This medication should not be administered to patients with specific allergic reactions, asthma, severe peptic ulcers, severe heart, kidney, or liver diseases, bleeding disorders, pregnant women, nursing mothers, children, and adolescents. Patients with esophagitis, gastritis, blood disorders, kidney or liver dysfunction, and the elderly should be monitored more closely when administered this medication, and drug interactions should also be taken into account. Various side effects affecting the nervous, digestive, circulatory, respiratory systems, blood, skin, etc., may occur infrequently; thus, any abnormal symptoms should be immediately reported to medical personnel. Women who are pregnant or nursing should not take this medication, and women who plan to become pregnant should also avoid its use. In case of overdose, gastrointestinal disturbances or neurological symptoms may occur, requiring immediate medical intervention. This medication should be diluted in a sterile environment and used as soon as possible after dilution; for storage, it should be kept away from direct sunlight and in a cool place. Safety and efficacy have not been established for children and adolescents; therefore, it should not be used in these populations, and elderly patients should start with a low dose and be closely monitored.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, urinary issues

Mild side effects

• Loss of consciousness
• insomnia
• fatigue
• fever
• sensory disturbances
• tinnitus
• vomiting
• abdominal pain
• dyspepsia
• obstruction

This medication is sensitive to light; therefore, it should be stored in a light-protective container. Additionally, it is advisable to store the medication at room temperature between 1 to 30 degrees Celsius. Storing it this way helps maintain the medication's efficacy and safety.

Appearance

This medication is an injection solution in a colorless, transparent liquid contained in a brown glass ampoule.

Package unit

2mL x 20 ampoules