Neobet 20 mg (Rabeprazole Sodium)

Adult dose

Gastric ulcer, duodenal ulcer: Typically, 10 mg is administered orally once daily and can be increased to 20 mg once daily based on symptoms. Treatment duration for gastric ulcers is up to 8 weeks and for duodenal ulcers is up to 6 weeks. Erosive or ulcerative gastroesophageal reflux disease: 10 mg or 20 mg is administered orally once daily for 4-8 weeks. If treatment fails after 8 weeks, a continuous therapy of 10 mg or 20 mg twice daily for an additional 8 weeks may be initiated, with 20 mg twice daily only for patients with severe mucosal damage. Symptom relief for gastroesophageal reflux disease: 10 mg is administered once daily. If symptoms are not controlled after 4 weeks, further medical consultation is needed. After symptoms resolve, an on-demand therapy of 10 mg once daily can be employed to manage any subsequent symptoms. Long-term maintenance therapy for gastroesophageal reflux disease: Depending on the patient, 10 mg or 20 mg is taken orally once daily. Helicobacter pylori eradication: Patients infected with Helicobacter pylori must be treated with eradication therapy. It is recommended to combine this drug at a dosage of 20 mg with clarithromycin 500 mg and amoxicillin 1 g, administered twice daily for 7 days. Zollinger-Ellison syndrome: The recommended initial dose for adults is 60 mg once daily. The dosages can be adjusted up to 120 mg daily based on the individual patient's needs. Dosages up to 100 mg can be given once daily, while 120 mg should be divided into two doses of 60 mg each. Patients with Zollinger-Ellison syndrome have experienced up to 1 year of treatment with this medication. ◯ Hepatic impairment patients Adverse reactions associated with hepatic encephalopathy have been reported in patients with liver cirrhosis. Therefore, it should be administered cautiously. ◯ Pediatrics Safety in pediatric patients has not been established. ◯ Geriatrics It should be administered cautiously as many elderly patients may have impaired liver function.

This medication should not be used in patients with allergies to specific components or benzimidazole derivatives, or those who have experienced such reactions in the past. Furthermore, when used in combination with amoxicillin or macrolide antibiotics for the eradication of Helicobacter pylori, this medication should not be used in patients with allergies to these antibiotics. Patients taking specific drugs like terfenadine, cisapride, pimodone, or astemizole should exercise caution as it may be risky when used in combination. It is recommended not to administer this medication to patients taking atazanavir or rilpivirine. Pregnant or nursing women should not take this medication as its safety has not been established. Patients with impaired liver function or the elderly may have a higher risk of side effects, so it should be administered cautiously. Hypersensitivity reactions may include rash, urticaria, and itching; administration should be immediately stopped if such symptoms occur. Blood-related abnormalities may show decreased or increased red or white blood cell counts, hence regular blood tests are necessary. Liver function tests should also be conducted regularly, and if symptoms of hepatitis or jaundice occur, medication should be immediately discontinued. Cardiovascular symptoms such as hypertension, myocardial infarction, or abnormal electrocardiograms may occur rarely, so caution is necessary. Gastrointestinal side effects may include diarrhea, abdominal pain, nausea, vomiting, or appetite changes; in severe cases, consultation with healthcare professionals is needed. Neurological symptoms may manifest as headaches, insomnia, anxiety, or dizziness; caution is needed when driving or operating machinery. Respiratory symptoms such as cough, dyspnea, or asthma may occur, so any worsening of respiratory symptoms should be reported to healthcare professionals immediately. Musculoskeletal pain, skin rashes, alopecia, or severe skin reactions (such as Stevens-Johnson syndrome) may occur; medication should be immediately discontinued if abnormal symptoms arise. Anomalies in special senses such as vision changes, tinnitus, or hearing loss have been reported, so attention to eye health is necessary. Urological abnormalities such as hematuria or difficulty urinating may occur; if symptoms are present, consultation with healthcare professionals is needed. Long-term use may increase the risk of fractures related to osteoporosis, so regular bone density tests are recommended for long-term users. This drug strongly inhibits gastric acid secretion, which may slightly increase the risk of bacterial infections in the stomach and caution should be taken against diarrhea caused by Clostridium difficile. Caution is advised during driving or machinery operation as drowsiness or dizziness may occur. There may be interactions with other medications, so if currently taking any other drugs, they must be reported to healthcare professionals, and caution is particularly necessary when taken in combination with warfarin, methotrexate, atazanavir, or antibiotics. This medication should be taken whole without chewing or breaking, and should be stored out of reach of children. Long-term use of this medication may lead to Vitamin B12 absorption disorders, so supplementary treatment may be necessary if required. If manifestations of autoimmune diseases such as cutaneous or systemic lupus erythematosus appear during treatment, discontinue the medication and seek evaluation from a specialist. In case of overdose, as there is no specific antidote, treatment should be provided according to symptoms, and care should be taken to avoid overdose.

Serious side effects

Urticaria, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, high fever, severe rash, blisters, skin peeling, pain in mucous membranes of the mouth/eyes, difficulty breathing or shortness of breath, asthma attacks, respiratory problems accompanied by cough and fever, yellowing of the skin or eyes (jaundice), generalized lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, significantly decreased urine output,

Mild side effects

• Rash
• itching
• decreased red blood cell count
• decreased white blood cell count
• increased white blood cell count
• increased eosinophil count
• increased neutrophil count
• decreased lymphocyte count
• anemia
• purpura

This medication must be kept in a sealed container to prevent exposure to air or moisture. It is important to maintain the storage temperature between 1 degree and 30 degrees Celsius.

Appearance

Pale yellow round enteric-coated tablet

Package unit

28 tablets (7 tablets/PTP × 4)