Glimepiride Tablets 4 mg (Glimepiride)

Adult dose

For patients who have never received this medication before, the initial dose is 1 mg of Glimepiride once daily. If necessary, the dose may be increased by 1 mg at intervals of 1 to 2 weeks. Generally, there is little additional effect when doses above 4 mg are administered; however, some patients have shown better metabolic control at doses of 6 mg (or 8 mg). A dose of 4 mg once daily may fail if

This medication should not be used in patients with insulin-dependent diabetes mellitus or those in diabetic ketoacidosis or coma. Additionally, it should not be administered to patients allergic to this medication or its components, including sulfonylureas. Patients with lactose intolerance or certain genetic metabolic disorders should also avoid use. It is not recommended for patients with severe liver or kidney impairment, and women who are pregnant or may become pregnant, or are breastfeeding, should not use this medication. Patients with severe infections, pre- and post-surgery, or severe trauma may require insulin therapy. Patients with gastrointestinal disorders that affect food absorption should use caution due to the risk of hypoglycemia. During the initial dosing, the risk of hypoglycemia is high, so blood glucose levels should be monitored carefully. Elderly patients, those with poor nutritional status or irregular eating patterns, those with an imbalance of exercise and meal timing, and those who frequently consume alcohol are at greater risk for hypoglycemia. Caution is also necessary for patients with impaired liver or kidney function or who are taking other medications. Patients with these risk factors should inform their physician or pharmacist in advance, and dosage adjustments or changes in administration methods may be required. This medication can cause hypoglycemia, and symptoms of hypoglycemia may include headache, severe hunger, nausea, fatigue, confusion, drowsiness, or loss of consciousness. Visual disturbances, gastrointestinal disturbances, liver function abnormalities, blood abnormalities, and allergic reactions have been reported; if any adverse symptoms occur, immediate consultation with a physician is necessary. Severe allergic reactions or severe hypoglycemia can be life-threatening and require urgent intervention. This medication should be taken in conjunction with dietary and exercise therapy to assist in blood sugar control, and consuming sugar during episodes of hypoglycemia typically leads to rapid recovery. Blood sugar and liver and kidney function should be regularly monitored during treatment, and consultation with a physician is necessary when discontinuing or changing medication. When taken with other medications, blood sugar control may be affected, so it is essential to disclose any medications being taken. Caution is advised, particularly with specific antibiotics, anticoagulants, steroids, beta-blockers, and alcohol, as these can alter the effectiveness of this medication. Pregnant or breastfeeding women are advised to consider insulin therapy instead, as it may affect the fetus or newborn. The safety in children under 18 has not been established, and elderly patients may require dosage adjustments due to decreased kidney function. In case of overdose, severe hypoglycemia may occur, necessitating immediate medical attention and treatment. If symptoms of hypoglycemia appear, rapid sugar intake or assistance from healthcare professionals is needed. This medication should be kept out of reach of children and stored in its original container for safety.

Serious side effects

Urticaria, severe swelling (edema), difficulty breathing, hypotension, shock, skin and mucous membrane reactions (Stevens-Johnson syndrome), anaphylaxis, angioedema, liver function abnormalities (cholestasis, jaundice), severe hypoglycemia, convulsions, loss of consciousness, coma, thrombocytopenia, leukopenia, hemolytic anemia, erythrocytopenia, agranulocytosis, pancytopenia, thrombocytopenic purpura

Mild side effects

• Headache
• severe hunger
• nausea
• vomiting
• fatigue
• sleep disturbances
• anxiety
• aggression
• decreased concentration
• reduced motivation

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture and kept at room temperature between 1 to 30 degrees Celsius. Storing it this way helps maintain its efficacy for a longer period.

Appearance

Pale blue oval-shaped tablet

Package unit

30 tablets/box [10 tablets/PTPX3], 100 tablets/bottle