Cosatin Plus Tablet

Adult dose

The standard dosage is one tablet of Losartan potassium 50 mg/hydrochlorothiazide 12.5 mg once daily. Dosages exceeding Losartan potassium 100 mg/hydrochlorothiazide 25 mg are not advisable. - In cases where blood pressure control is difficult with either Losartan or hydrochlorothiazide monotherapy, start with one tablet of 50 mg/12.5 mg once daily, and if the blood pressure is not controlled after three weeks, it can be increased to a maximum of

Child dose

There is no experience of use in children and adolescents (under 18 years of age), so this medication is not administered to them.

This drug may cause serious harm to the fetus, especially when taken during the second and third trimesters of pregnancy; therefore, it should be discontinued immediately upon confirmation of pregnancy. Patients who are allergic to any ingredients in this drug or who have certain kidney and liver diseases, electrolyte imbalances, etc., should not use it. Patients with severely low blood pressure or significantly impaired kidney function and those with certain genetic conditions should also refrain from taking this medication. Since blood pressure may drop rapidly upon administration, caution is necessary for patients with hypotension, and those with weakened kidney or liver function should use it carefully. During the use of this drug, electrolyte levels in the blood should be regularly monitored for abnormalities, and extra caution is required when symptoms such as dehydration, vomiting, or diarrhea occur. The hydrochlorothiazide component may increase sensitivity to sunlight, so sunlight exposure should be limited, and skin protection should be observed. This drug may interact with various medications; therefore, if you are taking other medications, it is imperative to consult your doctor or pharmacist. Dizziness or drowsiness may occur during the initial use or when changing the dosage; therefore, caution is required when driving or operating machinery. Elderly patients may experience adverse reactions more frequently, so they should take it carefully, and it should not be used in children or adolescents. While taking this drug, it is essential to have regular blood tests and health checks as directed by your doctor.

Serious side effects

Hives, severe swelling (edema), angioedema (may cause airway obstruction due to laryngeal/glottic swelling, swelling of the face/lips/pharynx/tongue), chest tightness, difficulty breathing, acute respiratory distress syndrome (ARDS), acute angle-closure glaucoma, jaundice, thrombocytopenia, severe skin adverse reactions (severe rash, blistering, desquamation, mucocutaneous syndrome (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell syndrome)), severe

Mild side effects

• Systemic: Abdominal pain, weakness, fatigue, fever, malaise, dizziness, fainting, headache
• Cardiovascular: Palpitations, angina, arrhythmia, hypotension, myocardial infarction, secondary AV block
• Gastrointestinal: Loss of appetite, constipation, toothache, dry mouth, dyspepsia, flatulence, gastritis, vomiting, nausea, diarrhea
• Musculoskeletal: Back pain, arm pain, joint pain, arthritis, fibromyalgia, hip pain, joint swelling, knee pain, leg pain, muscle cramps, muscle weakness

This medication is light-sensitive; therefore, it should be stored in a container that does not allow light to enter. Additionally, it is important to maintain the storage temperature between 1 to 30 degrees Celsius to preserve the drug's efficacy over time.

Appearance

Yellow oval film-coated tablet

Package unit

30 tablets/bottle, 300 tablets/bottle, 100 tablets/bottle (for export)