Brenzept Tablets 10 mg (Donepezil Hydrochloride Hydrate)

Adult dose

Donepezil Hydrochloride should be administered once daily at 5 mg before bedtime. If abnormal dreams, nightmares, or sleep disturbances occur, morning dosing may be considered. Donepezil reaches a steady state within 15 days of administration, so a dosage of 5 mg should be given for 4–6 weeks. After evaluating the clinical response during this period, it may be increased up to 10 mg. If increasing to 10 mg daily, caution should be exercised regarding gastrointestinal adverse reactions.

Child dose

No experience of use in pediatric patients.

This medication contains Donepezil Hydrochloride Hydrate as its main component and is used for the treatment of symptoms of Alzheimer’s type dementia. This medication should not be administered to certain patients. For instance, individuals allergic to this medication or its components, women who are pregnant or breastfeeding, and individuals with genetic issues such as lactose intolerance should not use it. Patients with heart disease, a history of peptic ulcers, or those suffering from asthma or obstructive pulmonary diseases should use this medication cautiously due to its potential effects on heart rate and digestive organs. This medication may cause various adverse reactions, so if symptoms such as fainting, heart problems, gastrointestinal bleeding, liver dysfunction, seizures, muscle pain, or shortness of breath occur during use, medical consultation should be sought immediately. While used for dementia treatment, it is not approved for other types of memory disorders, and discontinuation should be considered if deemed ineffective. Due to potential side effects related to heart rate, patients with heart conditions may require regular electrocardiogram tests. Additionally, it may increase gastric acid secretion, worsening peptic ulcers, so patients with gastrointestinal disease history should be cautious. Caution is advised when driving or operating machinery as dizziness or fatigue may occur. This medication may interact with other drugs; therefore, consultation with a healthcare provider regarding any concurrent use of heart-related medications, antibiotics, antidepressants, or anticonvulsants is recommended. Women who are pregnant or breastfeeding are advised against using this medication without professional consultation if absolutely necessary. Safety in children has not been established, and it should not be used in pediatric patients. Severe symptoms such as nausea, vomiting, bradycardia, and respiratory depression may occur in case of overdose, so it is crucial to adhere strictly to the prescribed dosage, and if overdose is suspected, an immediate visit to a medical facility is necessary. Finally, this medication should be stored out of reach of children and should not be transferred to another container.

Serious side effects

Fainting, bradycardia, heart block, QT interval prolongation, myocardial infarction, heart failure, peptic ulcers, perforated duodenal perforation, gastrointestinal bleeding, hepatitis, liver dysfunction, jaundice, cerebral seizures, epilepsy, convulsions, cerebral hemorrhage, cerebrovascular disorders, extrapyramidal symptoms (movement disorders, ataxia, dyskinesia, muscle rigidity, tremors, involuntary movements, gait disturbances, abnormal posture, speech disorders), neuroleptic malignant syndrome (stupor, muscle rigidity,

Mild side effects

• Nausea
• vomiting
• diarrhea
• loss of appetite
• dizziness
• insomnia
• headache
• fatigue
• tremors
• drowsiness

This medication should be stored in a tightly closed container that is airtight, at room temperature between 1 and 30 degrees Celsius. Storing this way will help maintain the medication's efficacy.

Appearance

Yellow round film-coated tablet

Package unit

30 tablets/bottle