K-Myril Tablet 2 mg (Glibenclamide)

Adult dose

Administer 1 time daily orally. Start with 1 mg of glibenclamide, increasing the dose by 1 mg every 1-2 weeks as necessary. Generally, there is little additional benefit when doses of 4 mg or more are administered, but some patients may increase the dosage to 6 mg or 8 mg. If administration of 4 mg per day fails, consider transitioning to insulin therapy or combination therapy. This medication should be taken before breakfast or the first meal of the day.

This medication should not be used in patients with insulin-dependent diabetes or diabetic ketoacidosis, or patients in a comatose state. Patients who are allergic to this medication or its components, or those with severe liver or kidney dysfunction should not take it. It is advisable for pregnant women or those who may become pregnant and breastfeeding women to avoid this medication. In cases of severe infections or before/after surgery, or in cases of severe trauma, transitioning to insulin therapy is recommended. Disorders such as diarrhea or vomiting may impede the absorption of this medication, increasing the risk of hypoglycemia. During the first week of taking this medication, the risk of hypoglycemia is high, so blood sugar should be monitored frequently. This is particularly important for the elderly, individuals in poor nutritional status or with irregular meals, those with improper balance between exercise and diet, and frequent alcohol consumers. Patients with impaired liver or kidney function and those taking multiple medications should also closely monitor blood sugar changes. If hypoglycemic symptoms occur or if there is a high risk of hypoglycemia, dose adjustments or changes in administration may be necessary. Taking this medication can cause hypoglycemic symptoms, which may include headaches, severe hunger, nausea, fatigue, drowsiness, confusion, trembling, and dizziness. In severe cases, loss of consciousness or convulsions may occur, so if symptoms arise, immediate intake of sugar or consultation with medical personnel is necessary. Also, rare side effects such as visual impairment, indigestion, liver function abnormalities, blood disorders, and allergic reactions may occur, so any unusual symptoms should be reported promptly. Regular intake of this medication along with diet and exercise is essential for optimal blood sugar control. If hypoglycemia occurs, sugar or sugar-containing drinks should be consumed to rapidly elevate blood sugar; artificial sweeteners are not effective. Blood sugar control may become difficult during stressful situations, surgery, or infection, and temporary transition to insulin therapy may be required. Additionally, caution should be exercised while driving or operating machinery due to the risk of accidents from hypoglycemic or hyperglycemic symptoms. This medication interacts with many other drugs, which may impact blood sugar control depending on the medications taken concurrently. Special caution should be taken when used in combination with certain antibiotics, antifungals, antihypertensives, anti-inflammatory drugs, and beta-blockers, and it is important to inform the physician or pharmacist of all medications being used. Pregnant or breastfeeding women should avoid this medication due to potential effects on the fetus or newborn, and if necessary, insulin therapy is a safer alternative. This medication is not used in children under 18 years of age, as safety and efficacy have not been established. Elderly patients may have decreased kidney function, so dosage adjustments should be made as needed. In the case of an overdose, severe hypoglycemia may occur, and immediate medical attention should be sought for appropriate treatment.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, chest tightness, pallor, severe rash with fever, blisters, skin peeling, soreness of oral/conjunctival mucosa, jaundice, extreme lethargy, sudden and severe headache, thunderclap headache, seizure, consciousness confusion, visual disturbances, paralysis, significantly reduced urine output, severe edema with increased blood pressure, thrombocytopenic purpura, anaphylaxis, angioedema, mucocutaneous lesions

Mild side effects

Headache, severe hunger, nausea, vomiting, fatigue, sleep disturbances, anxiety, aggression, decreased concentration, decreased agility or activity levels, depression, confusion, speech disturbances, aphasia, visual impairment, tremors, partial paralysis, sensory disturbances, dizziness, weakness, loss of self-control, temporary mental confusion, drowsiness, bradycardia, sweating, cold and clammy skin, tachycardia, hypertension, palpitations, angina, deep vein thrombosis, blurred vision, fullness or pressure in the upper abdomen

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. The temperature should be maintained between 1 and 30 degrees Celsius.

Appearance

Green oblong tablet

Package unit

30 tablets/bottle, 300 tablets/bottle