Simvastatin 40 mg Tablets (Simvastatin)

Adult dose

1. For reduction of risk of cardiovascular disease: 40 mg once daily in the evening. 2. For hyperlipidemia: Typically, 20 mg once daily in the evening, while mild to moderate hypercholesterolemia patients may start at 10 mg. 3. Administer 5-40 mg once daily in the evening, and cholesterol levels should be measured at 4 weeks and afterwards to adjust the dosage. 4.

Child dose

Patients aged 10-17 years are recommended an initial dose of 10 mg once daily in the evening, with a recommended dose range of 10-40 mg per day, and a maximum dose of 40 mg per day. Dosage should be adjusted according to treatment needs.

This medication can cause muscle-related issues, potentially leading to myopathy or rhabdomyolysis. The risk can be increased, particularly when taken at high doses or in combination with certain medications. Patients with hypersensitivity to this medication, liver function impairment, pregnant or nursing women, and those taking powerful CYP3A4 inhibitors or certain medications should not take this medication. Patients with liver dysfunction, reduced kidney function, hypothyroidism, history of muscle disorders, elderly patients, and women should be especially cautious while taking this medication, and regular testing may be required. While taking this medication, if symptoms such as muscle pain, weakness, or tenderness occur, it is important to inform a doctor immediately and have testing done. If adverse symptoms are confirmed, discontinuation of the medication is necessary. Since this medication is metabolized in the liver, regular liver function tests should be conducted, and if symptoms of hepatitis or liver function abnormalities occur, discontinuation of the medication should be immediate. This medication can interact with several other drugs, so it is crucial to inform healthcare providers of the current medications being taken when starting new ones. Women who are pregnant or may become pregnant should avoid taking this medication, and if pregnancy is confirmed while on this medication, it should be discontinued immediately and consultation with healthcare professionals should be sought. In pediatric and adolescent cases, the medication is used restrictively only if specific ages and conditions are met, as it may affect growth and sexual maturation, hence caution is required. Elderly patients may have increased blood concentrations of this medication, leading to a higher possibility of muscle-related adverse reactions; therefore, regular monitoring is needed during use. In cases of overdose, general emergency measures should be implemented, and if suspected, immediate medical attention is necessary. This medication should be kept out of reach of children and stored in its original container to prevent quality deterioration or misuse.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attack, cough with fever-joined respiratory abnormalities, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, vision abnormalities, paralysis, urination issues

Mild side effects

• Abdominal pain
• fatigue
• constipation
• diarrhea
• indigestion
• bloating
• nausea
• headache
• upper respiratory tract infection
• atrial fibrillation

This medication should be stored in a sealed container to protect it from air and moisture, and it is best kept at room temperature between 1 to 30 degrees Celsius. By storing it this way, the medication's effectiveness can be maintained for longer.

Appearance

Pink oval film-coated tablets

Package unit

30 tablets/bottle