Acladuo Dry Syrup (Amoxicillin Trihydrate · Clavulanate Potassium)

Adult dose

For recurrent tonsillitis and other upper respiratory infections, lower respiratory infections, urinary tract infections, and mild to moderate skin and soft tissue infections, take 25 mg/3.6 mg per kg of body weight divided into two doses per day. For severe infections such as otitis media, sinusitis, lower respiratory infections such as bronchopneumonia, and urinary tract infections, take 45 mg/6.4 mg per kg of body weight divided into two doses per day. To minimize potential gastrointestinal intolerance, administration during the early stage of meals is recommended.

Child dose

The 7:1 syrup is not suitable for children under 2 months of age and is also unsuitable for pediatric patients with renal impairment.

This medicine contains the artificial sweetener aspartame and should not be used by patients with phenylketonuria. Additionally, it should not be administered to patients who have had an allergy to this medicine or to beta-lactam antibiotics, patients with infectious mononucleosis or lymphocytic leukemia, and those with a history of liver dysfunction or jaundice. This product contains lactose and should not be taken by patients with genetic issues such as galactose intolerance, lactase deficiency, or glucose-galactose malabsorption. Patients with poor liver or kidney function, allergic constitution, elderly patients, or those with gastrointestinal diseases should use this medicine cautiously and consult a doctor immediately if unusual symptoms occur during use. This medicine can cause gastrointestinal side effects such as diarrhea, vomiting, or abdominal pain, and in severe cases can lead to serious conditions such as pseudomembranous colitis or acute pancreatitis, so caution is required. Hepatic side effects, such as abnormal liver function tests, hepatitis, or cholestatic jaundice, may also occur, warranting regular monitoring during prolonged use. Skin reactions such as rashes, itching, and in severe cases, conditions like Stevens-Johnson syndrome may occur; therefore, it is essential to discontinue use immediately if any abnormal reactions occur. Hematological side effects such as leukopenia, thrombocytopenia, anemia have been rarely reported, and there may be a tendency for bleeding, requiring caution. Effects on the central nervous system can lead to anxiety, confusion, and seizures, and acute renal failure or nephritis may occur in the kidneys, necessitating symptom observation. This medicine can interact with other drugs, especially when combined with anticoagulants, anti-inflammatory drugs, or antibiotics, so strict adherence to a doctor's instructions is essential. Use of this medicine is restricted for pregnant or nursing women; it is advisable to avoid use during the first trimester of pregnancy, and nursing mothers should carefully monitor for any adverse reactions in their infants. The safety of this medicine is not established for children, especially newborns under 2 months or premature infants, so its use is not recommended. Elderly patients may experience more pronounced unusual reactions due to declining physical functions, hence dose adjustment and observation are necessary. This product should be stored in a cool place between 1°C and 25°C in a tightly sealed container to protect it from air and moisture. By doing so, the effectiveness of the medication can be maintained for a longer period. In case of overdose, gastrointestinal symptoms or kidney failure, seizures may occur, requiring immediate medical attention for appropriate treatment. Finally, since prolonged use of this medicine carries the risk of resistant bacteria development, it is crucial to use it for the minimum necessary duration.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, anaphylaxis, skin and mucous membrane syndrome, shock, high fever with severe rashes, blisters, skin peeling, pain in oral/eye mucosa, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances.

Mild side effects

• Diarrhea
• pseudomembranous colitis
• dyspepsia
• stomatitis
• gastritis
• glossitis
• nausea
• vomiting
• loss of appetite
• abdominal pain

This medicine should be stored in a tightly sealed container to protect it from air and moisture, preferably in a cool place between 1°C and 25°C. Storing it this way helps maintain the effectiveness of the medicine for a long time.

Appearance

A white powder with a distinctive odor, a syrup that is to be dissolved for use.

Package unit

50mL/bottle, 500mL/bottle