Daewoong Gomsepine Injection 2.0 grams (Ceftriaxone Sodium Hydrate)

Adult administration

For adults and children over 12 years, administer 1-2g (equivalent) of ceftriaxone once daily by intravenous or intramuscular injection. In cases of severe illness or infections caused by moderately sensitive pathogens, the dose may be increased to 4g (equivalent) once daily. For gonorrhea treatment, a single intramuscular injection of 250mg (equivalent) is recommended. To prevent infections before and after surgery, administer 1-2g (equivalent) once, 30-90 minutes before surgery.

Child administration

For neonates (within 14 days of birth), administer 20-50mg/kg (equivalent) once daily, without exceeding 50mg (equivalent). For infants and children (from 15 days to 12 years), administer 2

This medication should not be mixed with solutions containing calcium or administered concurrently with other medications. Particularly in neonates, this drug should never be administered as it can react with calcium to form precipitates. Patients who are allergic to this medication or have had hypersensitivity reactions to cephalosporins or penicillins should not use it. Additionally, it should not be given to premature infants or neonates with jaundice, hypoalbuminemia, or acidosis. It should be administered cautiously to patients with a history of allergic reactions to this or similar medications, those with allergic tendencies, severe renal disease, and elderly or unwell patients. Blood tests and vitamin K administration may be necessary if needed. Using this medication can cause various side effects, including diarrhea, rash, liver enzyme abnormalities, decreased blood cell counts, headache, dizziness, pain at the injection site, fever, swelling, chills, increased serum creatinine, stomatitis, candidiasis, symptoms of vitamin K deficiency, symptoms of vitamin B group deficiency, ventricular extrasystoles, sweating, flushing, palpitations, nosebleeds, hypotension, Konis Syndrome, and pancreatitis. Severe allergic reactions or shock can occur, so patient status must be closely monitored during administration. This medication may interact with certain other medications, particularly diuretics or aminoglycoside antibiotics, which may affect renal function when used in combination. Caution is also required when combined with calcium or vitamin K antagonists. Women who are pregnant or nursing should consult a doctor before using this medication, and its use in neonates and premature infants is not recommended for safety. During treatment with this medication, dizziness may occur when driving or operating machinery, so caution is advised. Regular liver and kidney function tests are recommended. Prepared solutions should be used as soon as possible, and appropriate temperatures must be maintained during storage. This medication should only be used for the necessary duration to prevent the emergence of resistant microorganisms.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory distress accompanied by cough and fever, yellowing of skin or eyes (jaundice), generalized lethargy, sudden and very severe headaches, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, urinary retention

Mild side effects

• Eosinophilia
• leukopenia
• thrombocytopenia
• diarrhea
• rash
• increased liver enzymes
• headache
• dizziness
• bronchospasm
• loose stools

This medication should be stored in a sealed container to prevent air or moisture ingress, kept away from direct sunlight, and stored at room temperature. Adhering to appropriate storage methods will help maintain the drug's efficacy for a longer period.

Appearance

A colorless and transparent vial containing white to pale yellow powder

Package unit

1 vial, 10 vials