Myungmun Codeine Tablet

Adult dose

As Codeine Phosphate Hemihydrate, the dosage is 20 mg taken orally three times a day. This dosage may be administered up to four times a day at least every 6 hours. The maximum daily dosage must not exceed 240 mg. Dosage adjustments should be made according to symptoms.

Child dose

As Codeine Phosphate Hemihydrate, the recommended daily dosage is 30 to 60 mg, divided and administered at 6-hour intervals. The recommended daily dosage is based on weight (0.5 to 1 mg/kg). The maximum daily dosage should not exceed 240 mg.

This drug is metabolized in the liver and converted to morphine, so the metabolism rate can vary among patients; therefore, some patients may experience symptoms such as slowed breathing, confusion, insomnia, constricted pupils, constipation, and loss of appetite due to morphine toxicity. If any of these symptoms occur during treatment, the patient should discontinue the medication immediately and consult a physician. Particularly, it is advisable not to use this medication in patients under 18 who are obese, have obstructive sleep apnea syndrome, or severe pulmonary diseases. Furthermore, when taken with other medications that have central nervous system depressant effects or alcohol, there is a risk of severe sedation, respiratory depression, coma, or even death; hence, caution is required during concomitant use. This medication should not be administered to patients with acute respiratory depression, asthma attacks, severe liver dysfunction, heart failure due to chronic lung disease, seizure conditions, acute alcohol intoxication, hypersensitivity to opioid drugs, patients with hemorrhagic colitis, children under 12 years, breastfeeding mothers, or pregnant women. In patients with heart disease, liver or kidney dysfunction, shock, metabolic acidosis, hypothyroidism, adrenal insufficiency, a history of drug dependence or alcohol use disorder, the elderly, and children aged 13 to 18 with benign prostatic hyperplasia, caution is required, and the patient's condition should be closely monitored. Long-term use may lead to drug dependence, so the dosage should not be suddenly reduced or stopped, but rather gradually decreased as directed by a physician. Patients may experience drowsiness, dizziness, vision disorders, nausea, vomiting, constipation, arrhythmia, blood pressure changes, rash, itching, urinary difficulties, yawning, sneezing, tear flow, sweating, diarrhea, abdominal pain, pupil dilation, headache, anxiety, hallucinations, tremors, widespread muscle and joint pain, palpitations, confusion, and forgetfulness, so if any abnormal symptoms occur, consult medical personnel immediately. Drivers or those operating dangerous machinery should avoid such activities when experiencing drowsiness or dizziness. It is advisable for pregnant or breastfeeding women not to use this medication, and especially for breastfeeding women, as this drug may transfer to breast milk and cause serious side effects in infants. Therefore, breastfeeding should be discontinued. Children under 12 and those aged 18 and under with obstructive sleep apnea or who have undergone tonsillectomy or adenoidectomy should not use this medication. For the elderly, as the risk of respiratory depression is higher, treatment should start with a low dose and be administered cautiously. In case of overdose, respiratory depression, loss of consciousness, hypotension, and cardiac arrest may occur; immediate emergency treatment is required, and if necessary, administration of opioid antagonists and appropriate respiratory support is needed. This medication should be kept out of reach of children, and transferring it to other containers should be avoided, as it may cause accidents or degradation in quality. Finally, as this medication is metabolized by the liver enzyme CYP2D6, the effectiveness and side effects can vary depending on the level of activity of this enzyme. Some patients may metabolize this medication quickly, leading to higher morphine concentrations and increased toxicity risk, so caution is necessary.

Serious side effects

• Slow or shallow breathing
• difficulty breathing
• irregular breathing
• apneas
• severe respiratory depression
• seizures
• atelectasis
• bronchospasm
• laryngeal edema
• paralytic ileus

Mild side effects

• Confusion
• insomnia
• constricted pupils
• constipation
• loss of appetite
• drowsiness
• dizziness
• vision adjustments
• sweating
• nausea

This medication should be stored in a tightly closed container to prevent air or moisture from entering, and it is advisable to keep it at room temperature between 1 and 30 degrees Celsius. By storing it this way, the drug's efficacy can be maintained and deterioration prevented.

Appearance

White round tablet

Package unit

100 tablets (10 tablets/PTP x 10)