Glycerol Injection

Adult administration

As a standard, administer 200–500 mL of this drug via intravenous drip once 1-2 times a day, over 2-3 hours for every 500 mL. The treatment period is generally 1-2 weeks. For brain surgery, administer 500 mL via intravenous drip over 30 minutes to reduce brain volume. To lower intraocular pressure and reduce ocular volume during ophthalmic surgery, administer 300–500 mL via intravenous drip over 45-90 minutes. Adjust dosage according to age and symptoms.

This drug should not be administered to patients who are congenitally unable to metabolize glycerin or fructose properly, as there is a risk of severe hypoglycemia in such patients. Caution is required when administering this drug to patients with heart or circulatory system issues, as it may increase circulating blood volume and burden the heart. Patients with poor kidney function should also be cautious, as excessive amounts of water and sodium chloride in this drug may worsen kidney function. In patients with diabetes insipidus, it is important to manage electrolytes and fluids, but this drug may affect electrolyte balance and exacerbate symptoms. Diabetic patients need to be careful, as they may develop non-ketotic hyperosmolar coma. The use of this drug may occasionally cause gastrointestinal symptoms such as nausea or vomiting. Urinary tract abnormalities may also occur, such as blood in urine or increased urgency to urinate. Potassium levels in the blood may drop, and rarely, sodium levels may increase and blood glucose may rise sharply. Symptoms such as headaches, dry mouth, arm pain, elevated blood pressure, and fatigue may also occur. Rapid administration of large amounts of this drug can lead to serious metabolic abnormalities known as lactic acidosis; if symptoms occur, appropriate treatment should be sought immediately. When administering a high concentration of glycerol solutions or giving it rapidly, caution is needed as hemolysis, hematuria, kidney damage, hyperglycemia, and hyperosmotic states may occur. This drug must be used according to the prescribed dosage and method. In patients suspected of having acute subdural or epidural hematoma, it should be administered only after the cause of the bleeding has been removed and the risk of re-bleeding has been confirmed. Otherwise, intracranial pressure may suddenly drop and bleeding may recur. This drug contains sodium chloride, so it should be used with particular caution in patients who need to restrict sodium intake. Fructose is included, and rapid administration of high doses may cause lactic acidosis, hence caution is advised. In older adults, physiological functions are often impaired, so special care should be taken regarding fluid and electrolyte disturbances while administering the drug. Before administration, patients may feel the urge to urinate during ophthalmic surgery, so preoperative urination should be ensured. To prevent infections during administration, the patient’s skin and the equipment used should be thoroughly disinfected. In cold weather, it is recommended to warm this drug to body temperature before use. Once opened, the drug should be used immediately, and any remaining portion should be discarded; it should not be reused.

Mild side effects

• Nausea
• vomiting
• urinary hematuria reactions
• hemoglobinuria
• hematuria
• urinary urgency
• hypokalemia
• hypernatremia
• non-ketotic hyperosmolar hyperglycemia
• headaches

This drug should be stored in a sealed container to prevent air or moisture from entering. This helps maintain the drug's efficacy and prevents degradation.

Appearance

A colorless, transparent solution in a colorless transparent glass bottle or polypropylene, multilayer film plastic container

Package unit

200 mL/bottle, 500 mL/bottle