Samjin Diazepam Injection

Adult administration

1. Anxiety and tension: For severe cases, inject 5-10㎎ of diazepam; for mild or moderate cases, inject 2-5㎎ intravenously or intramuscularly. The dose may be repeated after 3-4 hours if needed. However, do not administer more than 30㎎ within 8 hours. 2. Adjunct for relief of skeletal muscle spasms: Inject 5-10㎎ of this drug intravenously or intramuscularly. The dose may be repeated after 3-4 hours if needed. Higher doses may be required for tetanus. 3. Adjunctive treatment of convulsive seizures or status epilepticus: Administer an initial dose of 5-10㎎ of this drug intravenously, followed, if needed, by slow intravenous injections at 10-15-minute intervals, up to a maximum of 30㎎. Consider the active metabolites that may remain; use with extreme caution in patients with chronic pulmonary disease or unstable cardiovascular status. 4. Premedication for anesthesia: Inject 10㎎ of this drug intramuscularly before surgery. 5. Alcohol withdrawal symptoms: Administer an initial dose of 10㎎ of this drug intravenously or intramuscularly. If needed, repeat 5-10㎎ doses after 3-4 hours. 6. Endoscopy: Administer 10㎎ or less of this drug intravenously. The dose may be increased to 20㎎ if needed. If intravenous injection is not possible, inject 5-10㎎ slowly intramuscularly 30 minutes before the examination. 7. Cardioversion: Inject 5-15㎎ slowly intravenously 5-10 minutes beforehand.

Child administration

Anxiety and tension — Administer 0.04-0.2㎎/kg intravenously. The dose may be repeated every 2-4 hours if needed. However, do not administer more than 0.6㎎/kg within 8 hours. Infants aged 1 month or older and children under 5 years — Slowly administer 0.2-0.5㎎ intravenously at 2-5-minute intervals, up to a maximum of 5㎎. The dose may be repeated every 2-4 hours if needed. Children aged 5 years and older — Slowly administer 1㎎ intravenously at 2-5-minute intervals until a maximum dose of 10㎎ is reached. The dose may be repeated every 2-4 hours if needed. Relief of convulsions in tetanus, infants aged 1 month or older and children under 5 years — Slowly administer 1-2㎎ intravenously. The dose may be repeated every 3-4 hours if needed. Relief of convulsions in tetanus, children aged 5 years and older — Slowly administer 5-10㎎ intravenously. The dose may be repeated every 3-4 hours if needed.

This drug contains benzyl alcohol, which may cause fatal respiratory symptoms in premature infants, thus caution is advised. When used with narcotics, the sedative effect may become excessively strong, leading to respiratory depression, coma, and potentially death, so co-administration should be done with great care. This medication should not be used in certain patients, such as those with acute glaucoma, severe myasthenia gravis, severe respiratory failure, or in patients with alcohol or drug dependence. In patients with compromised cardiac, liver, or kidney function, as well as older adults or those with depression, the effect of this drug may be enhanced, thus it should be administered with caution. Long-term use may lead to dependence or withdrawal symptoms, so it should be administered for the shortest duration possible, and upon discontinuation, the dose should be gradually reduced. This medication can cause drowsiness and decreased concentration, so driving or operating hazardous machinery should be avoided. It is advisable for women in early pregnancy or during lactation not to use this drug, and if unavoidable, consultation with a healthcare professional is recommended. In cases of overdose, severe symptoms such as coma and respiratory depression may occur, requiring immediate medical attention. This drug interacts with various medications, necessitating caution when taken with other central nervous system depressants, antidepressants, or narcotic analgesics. If unusual reactions such as anxiety, agitation, hallucinations, or amnesia occur during use, immediate consultation with a doctor is advised.

• Dependence
• withdrawal symptoms
• rebound anxiety
• anxiety
• agitation
• depression
• irritability
• confusion
• hallucination
• psychosis

This medication may be sensitive to light, so it should be stored in an opaque, sealed container that prevents light exposure. Additionally, it is best to store the medication at a cool room temperature, between 1 to 30 degrees Celsius. Storing it this way maintains the medication's effectiveness and prevents deterioration.

Appearance

Brown ampoules containing a colorless or pale yellow liquid

Package unit

20 ampoules/box [2 mL/ampoule x 20]