Ingredient

Diphenhydramine

Diphenhydramine is an antihistamine that alleviates allergy symptoms and has sedative effects.

All medicines
71
Combination
71
OTC medication
71

MFDS ingredient code M040108

What does it do?

Diphenhydramine is primarily used as an antihistamine to alleviate allergic reactions and reduce itching. It also has sedative effects, making it useful for insomnia and preventing motion sickness. It can also be utilized as a topical agent to help with skin conditions and muscle pain relief.

Diphenhydramine works by blocking the action of histamine, a substance in the body that causes allergic reactions, thereby alleviating symptoms. It also acts on the central nervous system to produce sedative effects, reducing anxiety and insomnia. When applied to the skin, it helps reduce itching and inflammation.

Approved uses differ by product. Check each product's information for its actual use.

Good to know

Diphenhydramine has a stronger sedative effect compared to other antihistamines. For this reason, it is often used as a sleep aid and is available in various forms (oral and topical). It is distinguished from antihistamines specifically designed for motion sickness prevention.

Medicines containing this ingredient

Even with the same ingredient, strength, dosage form and how it is taken can differ.

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Even with the same ingredient, dosage and approved uses can differ by strength, dosage form and combined ingredients. Check each product's information before taking it.

Combined ingredients

Ingredients used together with this ingredient in combination products.

Questions about this ingredient

  • QIs Diphenhydramine also used for motion sickness?

    Diphenhydramine is an antihistamine with sedative effects, and explanatory materials state that it is also used for insomnia and preventing motion sickness. Since it can cause drowsiness, please avoid driving or operating machinery after taking it, and check that it does not overlap with other cold or allergy medications.

    Answers 1 · 2026.09.14

For anything that needs medical judgment, consult a doctor or pharmacist.

SourceKorea Ministry of Food and Drug Safety (Drug Safety Korea)

This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.