Azathioprine Tablet 12.5 mg (Azathioprine)

Adult dose

After kidney transplantation: Initially, administer azathioprine orally at 3-5mg/kg body weight per day; the maintenance dose is 0.5-2mg/kg body weight. For creatinine clearance of 20mL/min or less, do not exceed 1.5mg/kg body weight per day. Autoimmune diseases: Administer 2.0-2.5mg/kg body weight per day for treatment of diseases other than chronic active arthritis. For treatment of chronic active arthritis, administer 1.0-1.5mg/kg body weight per day. The tolerated and effective doses vary by patient; therefore, adjust the dose carefully to achieve the optimal therapeutic effect. Consider discontinuing treatment if the condition has not improved after 12 weeks. The dose may be adjusted as appropriate according to age and symptoms.

This medication should not be used in certain patients. For example, patients with allergies to this medication or similar drugs, those with severe liver, kidney, or bone marrow diseases, and women who are pregnant or breastfeeding should not take this medication. This medication should be used cautiously in patients with bone marrow function impairment, those with infections, and patients with liver or kidney function issues. Additionally, caution is required for patients with chickenpox or those taking certain medications concomitantly. This medication can suppress immune function, increasing the risk of infections and causing side effects such as decreased blood cell counts. Serious side effects may include gastrointestinal problems, skin rashes, liver function abnormalities, and pneumonia, so if any unusual symptoms occur, you should consult a doctor immediately. During treatment, regular blood tests and liver function tests should be conducted, and if any abnormal findings are detected, the dosage may need to be adjusted or the medication discontinued. Additionally, long-term use may increase the risk of tumor occurrence, so caution is warranted. This medication can interact with other drugs, so if you are taking any other medications, be sure to inform your doctor or pharmacist. Caution is especially needed when taken concurrently with certain antibiotics, anticoagulants, and immunosuppressants. Women who are pregnant or may become pregnant should not take this medication, and breastfeeding should be avoided or stopped if using this medication. Particular caution is required in children and the elderly, and careful monitoring of kidney and liver function is essential. In case of overdose, there is a risk of severe bone marrow suppression, infection, and bleeding, so immediate medical attention should be sought. This medication should be stored in a safe place out of the reach of children and it is important to keep it in its original container. Finally, since this medication can suppress immune function, increasing the risk of infections and tumors, regular check-ups and careful observation are essential during treatment.

• Infection
• progressive non-Hodgkin lymphoma
• skin cancer
• sarcoma
• cervical cancer
• bone marrow dysfunction
• leukopenia
• thrombocytopenia
• anemia
• agranulocytosis

This medication should be stored in a sealed container to protect it from air and moisture, and it is important to store it at room temperature, between 1 to 30 degrees Celsius. Additionally, it should be kept away from direct sunlight to maintain its efficacy.

Appearance

Pale yellow round tablet

Package unit

100 tablets/box [10 tablets/PTP * 10 EA]