Twinklelo Tablets 80/5/25 Milligrams (Telmisartan, Amlodipine, Chlorthalidone)

Adult dose

This medication should be taken once daily, 1 tablet with water regardless of meals. It is recommended to take it at the same time each day (e.g., in the morning). Before administration, it is recommended to adjust the dosage based on individual components. For patients whose blood pressure is not controlled, a dosage of 40/5/12.5 milligrams may be administered, with adjustments made at intervals of more than 2 weeks. The maximum dosage is 80/5/25 milligrams.

This medication may pose serious risks to the fetus and newborn during pregnancy, particularly during the second and third trimesters, so it should not be used by women who are pregnant or may become pregnant. Patients with impaired liver function or progressive liver disease should exercise caution when taking this drug due to the potential for serious side effects such as hepatic coma. Patients with severe kidney disease may experience elevated blood urea nitrogen levels due to some components of this medication, such as the diuretic, and are at risk for drug accumulation, so careful administration is required. It is advised to avoid use if there is hypersensitivity to any of the ingredients, or if there are specific heart diseases, biliary obstructive diseases, severe liver disorders, or if breastfeeding. Among hypertension patients, certain kidney diseases, hypotension, heart failure, and diabetes patients require special caution when using this medication and should follow their doctor's instructions. Since this medication lowers blood pressure, dizziness or hypotensive symptoms may occur at the beginning of therapy; thus, caution is advised during driving or operating machinery. Electrolyte levels in the blood, especially potassium and sodium, should be monitored regularly during treatment to check for abnormalities. Interactions may occur when taken with other drugs, particularly with lithium, digoxin, non-steroidal anti-inflammatory drugs (NSAIDs), and simvastatin, so consultation with healthcare professionals is necessary when taking these medications together. Elderly patients may have reduced metabolic capacity for this drug; therefore, starting at a lower dose and gradually increasing it while paying special attention to dehydration and hypotension is recommended. In case of overdose, symptoms such as hypotension, arrhythmias, and renal dysfunction may occur, and immediate medical attention should be sought for appropriate treatment. This medication should be stored in a light-protective, tightly closed container, away from moisture, in a cool place, and should be kept away from the reach of children.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusional states, visual disturbances, paralysis, urinary issues

Mild side effects

• Dizziness
• dyslipidemia
• back pain
• rash
• orthostatic dizziness
• headache
• sensory loss
• abdominal pain
• rectal bleeding
• nausea

This medication should be stored in a light-protective, tightly sealed container and kept at room temperature between 1 and 30 degrees Celsius. Proper storage helps maintain the efficacy of the medication for an extended period.

Appearance

White oval biconvex tablet

Package unit

30 tablets/box[(6 tablets/PTP*5)]