Twinkle Clo 40/5/12.5 mg (Telmisartan, Amlodipine, Chlorthalidone)

Adult dose

This medication is taken once daily, one tablet, with water, regardless of meals. It is recommended to take it at the same time every day (e.g., in the morning). This medication may be administered at a dosage of 40/5/12.5 mg to patients whose blood pressure is not controlled with telmisartan/amlodipine combination therapy, and the dosage may be adjusted considering the patient's blood pressure response at intervals of more than 2 weeks. The maximum dosage of this medication is 80/5/25 mg.

This medication should not be taken by women who are pregnant, especially during the second and third trimesters, as it can cause serious harm to the fetus. Caution is needed in patients with liver function impairment or progressive liver disease, as this medication may induce hepatic encephalopathy. Patients with severe renal disease should use this medication cautiously, as some components may worsen renal function. Patients who have a history of allergy or hypersensitivity to this medication or its ingredients should avoid taking it. Use is contraindicated in specific patient groups such as pregnant women in the second and third trimesters, nursing mothers, patients with obstructive biliary disease, severe liver impairment, severe aortic stenosis, and patients in shock. This medication should be used with caution in patients with primary aldosteronism, heart valve diseases, gastrointestinal diseases, renal artery hypertension, severe hypotension, dialysis patients, and the elderly, requiring close observation by a physician. Dizziness, hypotension, electrolyte imbalance (especially changes in potassium, sodium, and calcium levels) may occur during use, so patients should consult healthcare professionals immediately if symptoms arise. When taking this medication, it may interact with other blood pressure medications, diuretics, lithium, digoxin, etc., so it is essential to inform the physician of all medications currently being taken. Caution is needed when driving or operating hazardous machinery, as drowsiness or dizziness may occur. In case of overdose, hypotension, cardiac arrhythmia, electrolyte imbalances, etc., may occur, necessitating immediate emergency treatment. Keep this medication out of the reach of children and store in a cool, dry place away from direct sunlight.

Serious side effects

Urticaria, severe swelling (edema), chest discomfort, chest pain, difficulty breathing, hypotension, weakness, thrombocytopenia, leukopenia, agranulocytosis, acute renal failure, intrahepatic cholestasis, jaundice, aplastic anemia, necrotizing vasculitis, pulmonary edema, pancreatitis, liver dysfunction, liver disease, vascular edema, anaphylactic reaction, vascular swelling, heart failure, congestive heart failure, cerebral infarction, hepatocellular carcinoma, acute renal failure (interstitial nephritis)

Mild side effects

• Dizziness
• orthostatic dizziness
• headache
• sensory deficit
• abdominal pain
• rectal bleeding
• nausea
• hemorrhagic gastritis
• constipation
• retinal hemorrhage

This medication is sensitive to light; it should be stored in a container that protects from light. Also, it should be stored at room temperature between 1 degree and 30 degrees Celsius to maintain its efficacy.

Appearance

White oval biconvex tablet

Package unit

30 tablets/box [(10 tablets/PTP*3)]