Plasmasolution Diu

Adult administration

For adults, 500 to 1000 mL is administered by slow intravenous infusion. The infusion rate should not exceed 0.5 g per kg of body weight within one hour when calculated as dextrose. The dosage and infusion rate should be adjusted appropriately according to age, weight, and symptoms.

This medication can cause allergic reactions, so if any symptoms of allergy appear, administration should be stopped immediately and appropriate treatment should be sought. When administering intravenous formulations containing dextrose, caution is necessary as there is a risk of vitamin B1 deficiency. Since it contains potassium, there may be a risk of hyperkalemia; therefore, patients with renal dysfunction or heart disease should consult medical personnel before use. In patients with impaired glucose tolerance, blood glucose levels may rise sharply, so frequent monitoring and control of blood glucose is necessary. Due to elevated sodium and chloride levels, this should be used cautiously in patients who may experience hypernatremia or fluid overload, and electrolyte status should be monitored regularly through blood tests. Patients at high risk for hyponatremia, especially children, the elderly, and those post-surgery, should be carefully monitored for signs of hyponatremia, and serum sodium levels should be monitored as needed. Excessive fluid supply may cause pulmonary edema or swelling; therefore, dosage and infusion rates should be adjusted, and the patient's condition should be continuously monitored. This medication should not be administered to patients with fluid overload, hypernatremia, hyperglycemia, or those with hypersensitivity to this medication. Patients with renal impairment, heart failure, or electrolyte imbalances should be particularly cautious when using this medication, and their condition should be confirmed through necessary tests. Pain or inflammation may occur at the injection site, and serious side effects such as cerebral edema or pulmonary edema may arise with rapid administration, so caution is required. Regular checks of blood glucose, electrolytes, and fluid balance are necessary, especially when used in combination with other medications due to potential interactions. Pregnant or breastfeeding women, neonates, children, and the elderly require more careful attention and monitoring when administering this medication. In case of overdose, there may be fluid overload and solute overload, so immediate notification of healthcare personnel and appropriate action must be taken. Before administration, check for abnormalities in the medication, disinfect the skin and equipment to prevent infection, and it is advisable to warm it to body temperature before use. To reduce the risk of air embolism during administration, do not use continuously connected methods.

Serious side effects

• Hives
• Severe swelling (edema)
• Difficulty breathing
• Severe allergic reactions
• Hyponatremic encephalopathy
• Cerebral edema
• Pulmonary edema
• Peripheral edema
• Cardiac arrest
• Fluid overhydration

Mild side effects

• Redness at the injection site
• infection
• thrombophlebitis
• phlebitis
• exudate
• fluid overload
• hyperkalemia
• hyperglycemia
• hyperosmolar hyperglycemic state
• hypernatremia

This medication should be stored in a sealed container to prevent air or moisture from entering, and it should be kept at room temperature between 1 to 30 degrees Celsius. Therefore, it is important to store it at an appropriate temperature, avoiding excessively hot or cold locations to maintain the drug’s efficacy.

Appearance

A transparent solution that is colorless to pale yellow, filled in a colorless, transparent plastic container for injection.

Package unit

500 mL/bag, 1000 mL/bag