Trubeta 40/5/12.5 mg Tablets (Telmisartan, Amlodipine, Chlorthalidone)

Adult dose

This medication is taken once daily, 1 tablet, with water, regardless of meal timing. It is recommended to take it at the same time every day (e.g., in the morning). For patients where blood pressure is not controlled by the Telmisartan/Amlodipine combination therapy, this drug at a dose of 40/5/12.5 mg may be administered, with dosage adjustments made considering the patient’s blood pressure response, spaced at least 2 weeks apart. The maximum dosage for this drug is 80/5/25 mg.

This drug should not be taken during pregnancy, especially in the second and third trimesters, as it may cause serious harm to the fetus. If pregnancy is confirmed, the medication should be discontinued immediately, and if necessary, substituted with other safe medications. Patients with liver function impairment or ongoing liver disease should use this drug with caution due to the risk of hepatic encephalopathy. In patients with severe kidney disease, some components of this drug may worsen kidney function, so it should be avoided or administered cautiously. Patients with an allergy to this drug’s ingredients or similar medications should not be administered this drug. Women who are pregnant or may become pregnant, nursing mothers, patients with cholestatic disease, patients with severe liver dysfunction, and patients with severe aortic stenosis should not take this medication. Caution is advised in diabetic patients or patients with moderate to severe renal impairment when used in combination with certain medications as it can be risky. When administered to the elderly, this drug should be started at a low dose and gradually increased, as electrolyte abnormalities such as hyponatremia or hypokalemia may occur, necessitating regular monitoring. During the use of this drug, side effects such as dizziness, hypotension, headache, and nausea may occur; thus, caution is needed while driving or operating dangerous machinery. As with other antihypertensives, excessive blood pressure reduction may increase the risk of myocardial infarction or stroke, so appropriate dose adjustments are essential. This drug may interact with specific medications, so if other medications are being taken, it is essential to consult with a physician or pharmacist. In case of overdose, symptoms such as hypotension, dizziness, and cardiac dysfunction may appear, and appropriate medical treatment must be sought immediately. When storing, keep out of reach of children, avoid direct sunlight, and store in a cool, dry place.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, skin peeling, oral/ocular mucosal pain, difficulty breathing or shortness of breath, asthma attack, breathing difficulties accompanied by cough and fever, yellowing of skin or eyes (jaundice), severe malaise, sudden and very severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination changes

Mild side effects

• Dizziness
• dyslipidemia
• lower back pain
• rash
• orthostatic dizziness
• headache
• sensory loss
• abdominal pain
• rectal bleeding
• nausea

This drug may be sensitive to light, so it should be stored in a light-resistant container. Additionally, it is important to store it at room temperature, between 1 to 30 degrees Celsius, to maintain the drug's efficacy.

Appearance

White oval biconvex bilayer tablet

Package unit

30 tablets/box (10 tablets/PTP×3)