Keglitto Tablets 25/5 mg (Empagliflozin, Linagliptin Besilate)

Adult dose

The recommended starting dose of this medication is 1 time daily with 10 mg empagliflozin and 5 mg linagliptin (6.67 mg linagliptin besilate). If the patient tolerates the initial dose and needs additional blood sugar control, the dosage may be titrated up to 25/5 mg (6.67 mg linagliptin besilate) once daily. Continue with the existing dose, taking the tablets whole without regard to meals. If a dose is missed, take it as soon as you remember; however, if the next scheduled dose is within 12 hours, skip the missed dose and continue as per the usual schedule. Do not double the dose on the same day.

This medication contains two active ingredients, empagliflozin and linagliptin, which assist in blood sugar control. However, this medication should not be used in certain patients for safety reasons. For instance, it should not be administered to individuals who have an allergy to the components, those with type 1 diabetes, diabetic ketoacidosis, or patients undergoing dialysis. Additionally, it should be used with caution in patients with decreased kidney function or heart failure. Because kidney function can influence the efficacy of this medication, it is important to regularly monitor kidney function before and during treatment. During the course of taking this medication, rare side effects such as acute pancreatitis or bullous pemphigoid may occur; thus, patients should inform their doctor immediately if they experience severe abdominal pain or skin blisters. The most common side effect is urinary tract infection, which may occur more frequently in women. Other possible symptoms include genital infections, increased urination, fluid loss, and symptoms of hypoglycemia. Particularly, when taken with sulfonylureas or insulin, there is an increased risk of hypoglycemia, so blood sugar levels should be monitored frequently, and medication dosage adjusted if necessary. This medication may lower blood pressure, thus requiring more caution for patients with cardiovascular disease, elderly patients, or those with hypotension. If dehydration or fluid loss is suspected, immediate consultation with medical personnel is necessary. Pregnant or nursing women are advised not to take this medication, and particularly during breastfeeding, it is recommended to discontinue breastfeeding. Moreover, caution is necessary when driving or operating machinery due to the risk of hypoglycemia. Long-term use of this medication may report an increased risk of amputations of toes or lower limbs, so it is crucial to manage foot health carefully. Lastly, during the course of this medication, interactions with other drugs may occur, so it is essential to inform your doctor or pharmacist if you are taking other medications.

Serious side effects

Hives, angioedema, ketoacidosis, pancreatitis, bullous pemphigoid, severe allergic reactions, severe hypoglycemia, congestive heart failure, pyelonephritis, urosepsis, necrotizing fasciitis (Fournier's gangrene), acute kidney injury, acute cholangitis, acute cholecystitis, cholangitis, acute pancreatitis, acute cholecystitis, acute cholangitis, acute cholecystitis, acute cholangitis, acute cholecystitis, acute cholecystitis, acute cholangitis, acute cholecystitis, acute cholecystitis, acute cholangitis

Mild side effects

• Urinary tract infection
• vulvovaginitis
• balanitis
• nasopharyngitis
• cough
• constipation
• oral ulcer formation
• itching
• rash
• hypoglycemia

This medication may be sensitive to air and humidity, so it should be stored in a tightly sealed container. It is recommended to maintain a storage temperature between 1 and 30 degrees Celsius. Proper storage will help preserve the medication's efficacy and safety over time.

Appearance

Flat on both sides with sharp edges, pink triangular film-coated tablet

Package unit

10 tablets/PTP, 30 tablets/PTP [(10 tablets/PTP×3)]