Xone Plus Tablet 5/80/12.5 mg (Amlodipine / Valsartan / Chlorthalidone)

Adult dose

This medication is to be taken once daily with one tablet regardless of meals, preferably at the same time each day (e.g., in the morning). For patients whose blood pressure is not controlled, administer 5/80/12.5 mg, and adjust the dosage at intervals of more than 2 weeks based on the patient's blood pressure response. The maximum dosage is 10/160/25 mg.

This medication can cause serious harm to the fetus and newborn if taken during pregnancy; therefore, it must be discontinued immediately upon confirmation of pregnancy. Patients with impaired liver function or those with ongoing liver disease should be cautious as serious side effects, such as hepatic encephalopathy, may arise from taking this medication. Patients with severely impaired kidney function may experience elevated blood urea nitrogen levels due to some components of this medication, which can lead to accumulation of the drug and related issues. Patients allergic to any component of this medication or those with hypersensitivity to specific drugs, pregnant or breastfeeding women, and patients with severe hypotension or serious liver or kidney disorders should not take this medication. Patients who are deficient in sodium or fluids should improve their condition prior to taking this medication, and if hypotension occurs, appropriate action should be taken immediately. Patients with high blood potassium levels or those taking other medications that can increase potassium should monitor potassium levels frequently and exercise caution. Patients with specific heart or kidney diseases, such as heart failure, post-myocardial infarction patients, or kidney transplant recipients, should exercise more caution when taking this medication. During the course of this treatment, side effects such as dizziness, headache, blood pressure drop, liver function abnormalities, and blood test abnormalities may occur, so it is necessary to consult healthcare providers if symptoms arise. This medication may interact with other drugs, so any other medications being taken should be reported to the healthcare provider. Elderly patients or children face a higher risk of side effects such as hypotension or electrolyte imbalances when taking this medication, necessitating dose adjustments and monitoring. In case of overdose, severe hypotension, shock, altered consciousness may occur, thus it is crucial to adhere to the prescribed dosage and seek immediate emergency care in case of unusual symptoms. This medication should be stored in a tightly sealed container to avoid exposure to moisture, heat, and light, and it is safer not to transfer to another container.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, peeling of skin, pain in oral/ocular mucous membranes, difficulty breathing or shortness of breath, asthma attack, respiratory abnormalities associated with cough + fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urine retention

Mild side effects

Dizziness, headache, increased blood uric acid, increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST), increased creatine phosphokinase (CPK), increased blood glucose, increased triglycerides (TG), COVID-19, nasopharyngitis, upper respiratory infection, eyelid tremor, orthostatic hypotension, chest discomfort, flushing, fatigue, edema, palpitations, lightheadedness, drowsiness, abdominal pain, nausea, weakness, malaise

This medication must be stored in a tightly sealed container to prevent air and moisture from entering. It is important to maintain a storage temperature between 1 to 30 degrees Celsius at room temperature to safely preserve the medication's efficacy.

Appearance

Yellow, rectangular, film-coated tablet

Package unit

30 tablets / bottle