XONE PLUS Tablets 5/160/12.5 mg (Amlodipine/Valsartan/Chlorthalidone)

Adult dose

Take one tablet once daily with water, regardless of meals. It is recommended to take it at the same time each day (e.g., in the morning). For patients whose blood pressure is not controlled with amlodipine/valsartan combination therapy, administer this medication 5/80/12.5 mg and adjust the dose at intervals of more than 2 weeks based on the patient’s blood pressure response. The maximum dosage of this medication is 10/160/25 mg.

This medication may cause serious harm to the fetus and newborn if taken during pregnancy, so it should be discontinued immediately upon confirmation of pregnancy. Patients with impaired liver function or progressive liver disease may experience serious complications such as hepatic coma when taking this medication, so caution is needed. In patients with severe kidney disease, some components of this medication may accumulate in the body, leading to issues such as hyperazotemia, thus it should be used with care. Patients who are hypersensitive to any ingredients in this medication or have specific liver or kidney diseases should not take it. Patients with severe hypotension or with certain heart valve diseases or in shock should also refrain from using this medication. In patients who are deficient in sodium or body fluids, administration of this medication may cause hypotension, so the patient's condition should be carefully reviewed and supplemented if necessary. Patients with high potassium levels or those taking potassium supplements should carefully monitor changes in potassium concentration. Patients with heart diseases such as heart failure or after myocardial infarction, as well as those with acute myocardial infarction, require special caution when administering this medication. Elderly patients may easily experience hypotension or electrolyte imbalances, so starting at a low dose and closely monitoring their condition is necessary. During treatment with this medication, neurological side effects such as dizziness or headache may occur, and routine blood tests may show abnormal liver function or electrolyte imbalances. In case of overdose, severe hypotension, shock, or impaired consciousness may occur, and immediate medical attention should be sought. Additionally, this medication may interact with other drugs; therefore, patients taking other medications should consult their doctor or pharmacist, especially when combining it with potassium-sparing diuretics or certain antibiotics. Finally, keep this medication out of reach of children and store it in a cool, dry place, away from direct sunlight and heat.

Serious side effects

Hives, severe swelling (edema), angioedema, toxic epidermal necrolysis, severe allergic reactions, severe rash with high fever, blisters, skin peeling, pain in mucous membranes of mouth/eyes, severe skin reactions, difficulty breathing or shortness of breath, asthma attacks, respiratory issues accompanied by cough and fever, breathing problems, yellowing of skin or eyes (jaundice), severe lethargy, liver problems (jaundice), sudden and severe headache,

Mild side effects

Dizziness, headache, increased blood uric acid, increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST), increased creatine phosphokinase (CPK), increased blood sugar, increased triglycerides (TG), COVID-19, nasopharyngitis, upper respiratory infection, eyelid twitching, orthostatic hypotension, chest discomfort, flushing, fatigue, swelling, palpitations, lightheadedness, drowsiness, abdominal pain, nausea, weakness, lethargy

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture, and the storage temperature should be maintained at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication for a longer duration.

Appearance

Light pink oblong film-coated tablet

Package unit

30 tablets/bottle