Xone Plus Tablets 10/160/25 mg (Amlodipine/Valsartan/Chlorthalidone)

Adult dose

This medication should be taken once daily with one tablet, regardless of meals, with water. It is recommended to take it at the same time each day (e.g., morning). For patients whose blood pressure is not controlled with a combination therapy of amlodipine and valsartan, a dosage of 5/80/12.5 mg should be administered, and dosage adjustments should be made at intervals of more than 2 weeks based on the patient's blood pressure response. The maximum dosage of this medication is 10/160/25 mg.

This medication may cause serious harm to the fetus and newborn if taken during pregnancy, and use should be discontinued immediately upon confirmation of pregnancy. Caution is required for patients with impaired liver function or those with progressive liver disease, as serious side effects such as hepatic coma may occur when taking this medication. Patients with severe kidney disease should be cautious, as some ingredients may increase blood nitrogen levels or pose a risk of drug accumulation in the body. Patients with allergies to any components of this medication or similar drugs, pregnant or potentially pregnant women, nursing mothers, and those with severe hypotension or liver and kidney disorders should not take this medication. Patients with severe heart valve disease, in shock, experiencing anuria, with a history of hypokalemia, hyponatremia, hypercalcemia, or gout should also avoid administration. Patients with sodium or fluid depletion should correct their condition before taking this medication and remain vigilant for symptoms of blood pressure reduction during treatment, seeking immediate care if necessary. Regular monitoring of potassium levels is required in cases where blood potassium levels are high or potassium-increasing medications are taken concurrently. Special observation is needed for patients with heart conditions, those who have undergone kidney transplants, or those with acute myocardial infarction to avoid excessively low blood pressure. Side effects such as dizziness, headache, blood pressure reduction, abnormal liver function, and increased blood uric acid levels may occur during treatment, and patients should consult healthcare professionals if symptoms arise. Elderly patients are at higher risk for dehydration, hypotension, and electrolyte imbalances and should start with a low dose, closely monitoring their condition during treatment. In cases of overdose, severe blood pressure reduction, shock, and arrhythmias may occur, requiring immediate hospitalization for appropriate treatment. This medication should be stored in a tightly sealed container to avoid exposure to moisture and heat and kept out of reach of children, as transferring it to another container may negatively impact quality.

Serious side effects

Urticaria, angioedema (swelling of the face, lips, pharynx, tongue), toxic epidermal necrolysis, hepatitis, jaundice, elevated liver enzyme levels, intrahepatic cholestasis, severe allergic reactions, heart failure, arrhythmias, atrial fibrillation, cardiovascular disorders, cerebral infarction, severe skin reactions, vesicular dermatitis, shock, syncope, loss of consciousness, hyperkalemia, acute renal failure, agranulocytosis, leukopenia, thrombocytopenia, pulmonary edema, pancreatitis, rhabdomyolysis

Mild side effects

Dizziness, headache, increased blood uric acid, increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST), increased blood creatine phosphokinase (CPK), increased blood glucose, increased blood triglycerides (TG), COVID-19, nasopharyngitis, upper respiratory infection, eyelid tremors, orthostatic hypotension, chest discomfort, flushing, fatigue, edema, palpitations, vertigo, drowsiness, abdominal pain, nausea, weakness, lethargy

This medication should be stored in a tightly sealed container to avoid exposure to air or moisture. It is important to maintain a storage temperature between 1 and 30 degrees Celsius.

Appearance

Dark pink oval film-coated tablet

Package unit

30 tablets/bottle