Xone Plus Tablet 10/160/12.5 mg (Amlodipine / Valsartan / Chlorthalidone)

Adult dose

Take one tablet once daily with or without food. It is recommended to take it at the same time each day (e.g., in the morning) whenever possible. For patients whose blood pressure is not controlled with the amlodipine/valsartan combination therapy, administer this medication at 5/80/12.5 mg, and adjust the dosage considering the patient's blood pressure response at intervals of more than 2 weeks. The maximum recommended dosage of this medication is 10/160/25 mg.

This medication can cause serious damage to the fetus and newborn if taken during pregnancy; therefore, it should be discontinued immediately upon confirmation of pregnancy. Patients with impaired liver function or ongoing liver disease may experience severe side effects such as hepatic encephalopathy while taking this medication. Patients with severe kidney disease may experience further deterioration of kidney function due to certain components of this medication, so careful use is necessary. Patients with allergies to any component of this medication or those with specific health conditions should not take it, particularly those with a history of severe hypotension, liver dysfunction, kidney dysfunction, or angioedema. Patients who are deficient in sodium or fluids may face a risk of hypotension, so their condition should be thoroughly assessed before taking it, following the physician's instructions. Patients with elevated potassium levels or those at risk of increasing potassium levels need to frequently monitor potassium levels when taking this medication with potassium supplements or potassium-sparing diuretics. Special caution is required for patients with specific diseases such as heart disease or kidney transplant recipients while taking this medication. Side effects such as dizziness, headache, and low blood pressure may occur while taking this medication, so if symptoms are severe, consult a doctor. Pregnant and breastfeeding women should avoid taking this medication due to unknown safety, and particularly those who are nursing are recommended to stop breastfeeding. Elderly patients are at higher risk of dehydration, hypotension, and electrolyte imbalances when taking this medication, so starting at a low dose and closely monitoring their condition is essential. In case of overdose, there is a risk of severe hypotension, shock, and coma; therefore, it is necessary to visit a hospital immediately for appropriate treatment. This medication should be stored in a tightly sealed container, away from direct sunlight, humidity, and heat, and should not be transferred to another container.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe allergic reaction, severe rash with high fever, blisters, skin peeling, oral/ocular mucosal pain, severe skin adverse reactions, shortness of breath or difficulty breathing, asthma attacks, breathing irregularities accompanied by cough and fever, respiratory problems, yellowing of the skin or eyes (jaundice), extreme fatigue, liver abnormalities (jaundice), sudden and

Mild side effects

Dizziness, headache, increased blood uric acid, increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST), increased creatine phosphokinase (CPK), increased blood glucose, increased blood triglycerides (TG), COVID-19, nasopharyngitis, upper respiratory infection, eyelid tremor, orthostatic hypotension, chest discomfort, vasculitis, weakness, fatigue, pain, weight gain/loss, hypotension, tension, sensory changes

This medication should be stored in a tightly sealed container to protect it from air or moisture and should be kept at a temperature between 1 and 30 degrees Celsius. Proper storage will maintain the medication's efficacy and safety.

Appearance

Pink rectangular film-coated tablets

Package unit

30 tablets/bottle