Jadigleemmet Tablet 12.5/1000 mg (Empagliflozin 2L-Proline, Metformin)

Adult dose

The recommended dosage is 1 tablet once, twice a day. Dosage should be determined based on each patient's current therapeutic regimen, efficacy, and tolerability without exceeding the maximum daily dosage of empagliflozin 25 mg and metformin 2000 mg. If blood glucose control is insufficient, empagliflozin 5 mg twice daily (total 10 mg) should be used along with the existing dose of metformin for patients with excellent tolerability and requiring additional blood glucose control.

This drug is used for the treatment of diabetes and helps with blood glucose control. When taking this drug, rare side effects such as severe lactic acidosis may occur, so caution is advised. Lactic acidosis is a condition in which lactic acid accumulates excessively in the body and can be life-threatening. Additionally, when taken with other diabetes medications, hypoglycemia may occur, hence careful monitoring of blood glucose levels is essential. Patients with impaired kidney function or acute renal injury may be at risk when taking this medication, so it is imperative to follow a physician's instructions. In cases of severe infection, dehydration, or reduced cardiac function, this medication should be discontinued or used cautiously. Before and after tests using iodine contrast agents, this medication should be temporarily discontinued and can be resumed once kidney function returns to normal. It is safest for women who are pregnant or may become pregnant, as well as nursing mothers, to avoid taking this medication. This drug can cause fluid loss, so special attention should be given to elderly patients or those with low blood pressure to prevent dehydration and ensure adequate fluid intake. As vitamin B12 levels may decrease, regular blood testing may be necessary for long-term use. Symptoms of genital infections or urinary tract infections may arise during use, and immediate notification to healthcare personnel is required if symptoms occur. Hypoglycemic symptoms may be present, so it is important to monitor for dizziness, cold sweat, tremors, and to consume sugar immediately if necessary. If surgery is planned, this medication should be stopped 48 hours prior to the surgery, and can be resumed after confirming normal kidney function post-surgery. This medication should be administered to the elderly with frequent monitoring of kidney function, and starting at the lowest dose is recommended. In cases of overdose, serious side effects such as lactic acidosis or hypoglycemia may occur, necessitating immediate medical attention. Finally, this medication should be kept out of the reach of children and stored in its original packaging.

Serious side effects

• Hives
• severe swelling (edema)
• angioedema
• hives
• chest tightness
• difficulty breathing
• lactic acidosis
• ketoacidosis
• increased serum creatinine
• decreased glomerular filtration rate

Mild side effects

• Hypoglycemia
• urinary tract infections
• genital infections
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication may be sensitive to air or moisture, hence it should be stored in a tightly sealed container. The storage temperature should be maintained between 1 degree and 30 degrees Celsius at room temperature to preserve the medication's effectiveness for an extended period.

Appearance

Brownish-purple, double-sided convex oval film-coated tablet

Package unit

30 tablets/bottle