Zadilirina Tablets 10/5 mg (Empagliflozin 2L-Proline, Linagliptin)

Adult dose

The recommended starting dose of this medication is once daily with empagliflozin 10 mg (equivalent to 15.107 mg of empagliflozin 2L-proline) and linagliptin 5 mg. If further blood glucose control is needed and tolerance is good, the dose may be increased to empagliflozin 25 mg/linagliptin 5 mg once daily (equivalent to 37.766 mg of empagliflozin 2L-proline). This medication can be taken irrespective of meals.

This medication contains empagliflozin and linagliptin as active ingredients and should not be administered to certain patients. For example, it should not be used in patients who are allergic to its components, those with type 1 diabetes, diabetic ketoacidosis, and patients undergoing dialysis. Additionally, patients with impaired kidney function or congestive heart failure should use this medication cautiously, and if skin conditions such as acute pancreatitis or bullous pemphigoid are suspected, treatment should be discontinued immediately. The most common side effect when taking this medication is urinary tract infection. Rarely, ketoacidosis, pancreatitis, hypersensitivity reactions, and hypoglycemia may occur. Special care is needed when taken in conjunction with insulin or sulfonylureas due to an increased risk of hypoglycemia. Ketoacidosis can occur regardless of blood sugar levels, and symptoms such as nausea, vomiting, abdominal pain, lethargy, and dyspnea should prompt immediate consultation with medical personnel. Patients at risk of dehydration or hypotension should carefully monitor their fluid status while taking this medication. This medication may increase the risk of genital fungal infections, so appropriate treatment is necessary if related symptoms occur. Elderly patients aged 75 or older should pay special attention to potential fluid volume loss. Caution is also advised while driving or operating machinery due to the risk of hypoglycemia, and the risk of limb amputation has been reported, necessitating thorough foot care. It is recommended that women who are pregnant or breastfeeding not use this medication, and it is also not indicated for children under 18 years of age. In case of an overdose, medical attention should be sought immediately, and this medication should be stored out of reach of children. It is also safe to store in the original packaging.

Serious side effects

• Urticaria
• angioedema
• ketoacidosis
• pancreatitis
• bullous pemphigoid
• Fournier's gangrene (perineal necrosis)
• vascular stent thrombosis
• vascular stent stenosis
• cerebrovascular accident
• acute renal impairment

Mild side effects

• Urinary tract infection
• vulvovaginal candidiasis
• vulvitis
• balanitis and other genital infections
• rhinitis
• cough
• constipation
• oral ulcer formation
• itching
• rash

This medication can be sensitive to air and moisture, so it must be stored in a tightly sealed container. It is important to maintain a storage temperature between 1 and 30 degrees Celsius. This helps to preserve the efficacy and safety of the medication.

Appearance

Pale yellow triangular film-coated tablets

Package unit

30 tablets / bottle